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10.1093/database/baw021 http://scihub22266oqcxt.onion/10.1093/database/baw021 C4792530!4792530!26980520     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Database+(Oxford) 2016 ; 2016 (ä): ä Nephropedia Template TP {{tp|p=26980520|t=2016. PolyQ 2 0: an improved version of PolyQ, a database of human polyglutamine proteins |pdf=|usr=}}{{26980520}} gab.com Text PolyQ 2 0: an improved version of PolyQ, a database of human polyglutamine proteins JO: Database (Oxford) http://www.kidney.de/pget.php?&tw=1&pmid=26980520 #FOAvip Proteins with expanded polyglutamine (polyQ) repeats are involved in human neurodegenerative diseases, via a gain-of-function mechanism of neuronal toxicity involving protein conformational changes that result in the formation and deposition of ?-sheet-rich aggregates. Aggregation is dependent on the context and properties of the host protein, such as domain context and location of the repeat tract. In order to explore this relationship in greater detail, here we describe PolyQ 2.0, an updated database that provides a comprehensive knowledgebase for human polyQ proteins. Compared with the previous PolyQ database, our new database provides a variety of substantial updates including detailed biological annotations and search options. Biological annotations in terms of domain context information, protein structural and functional annotation, single point mutations, predicted disordered regions, protein?protein interaction partners, metabolic/signaling pathways, post-translational modification sites and evolutionary information are made available. Several new database functionalities have also been provided, including search using multiple/combinatory keywords, and submission of new data entries. Also, several third-party plug-ins are employed to enhance data visualization in PolyQ 2.0. In PolyQ 2.0 the proteins are reclassified into 3 new categories and contain 9 reviewed disease-associated polyQ proteins, 105 reviewed non-disease polyQ proteins and 146 un-reviewed polyQ proteins (reviewed by UniProt curators). We envisage that this updated database will be a useful resource for functional and structural investigation of human polyQ proteins.Database URL:http://lightning.med.monash.edu/polyq2/ Twit Text FOAVip PolyQ 2 0: an improved version of PolyQ, a database of human polyglutamine proteins ????Database (Oxford) http://www.kidney.de/pget.php?&tw=1&pmid=26980520 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26980520 #FOAvip English Wikipedia <ref>{{Cite pmid|26980520}}</ref> PolyQ 2 0: an improved version of PolyQ, a database of human polyglutamine proteins #MMPMID26980520 Li C; Nagel J; Androulakis S; Song J; Buckle AM Database (Oxford) 2016[]; 2016 (ä): ä PMID26980520show ga Proteins with expanded polyglutamine (polyQ) repeats are involved in human neurodegenerative diseases, via a gain-of-function mechanism of neuronal toxicity involving protein conformational changes that result in the formation and deposition of ?-sheet-rich aggregates. Aggregation is dependent on the context and properties of the host protein, such as domain context and location of the repeat tract. In order to explore this relationship in greater detail, here we describe PolyQ 2.0, an updated database that provides a comprehensive knowledgebase for human polyQ proteins. Compared with the previous PolyQ database, our new database provides a variety of substantial updates including detailed biological annotations and search options. Biological annotations in terms of domain context information, protein structural and functional annotation, single point mutations, predicted disordered regions, protein?protein interaction partners, metabolic/signaling pathways, post-translational modification sites and evolutionary information are made available. Several new database functionalities have also been provided, including search using multiple/combinatory keywords, and submission of new data entries. Also, several third-party plug-ins are employed to enhance data visualization in PolyQ 2.0. In PolyQ 2.0 the proteins are reclassified into 3 new categories and contain 9 reviewed disease-associated polyQ proteins, 105 reviewed non-disease polyQ proteins and 146 un-reviewed polyQ proteins (reviewed by UniProt curators). We envisage that this updated database will be a useful resource for functional and structural investigation of human polyQ proteins.Database URL:http://lightning.med.monash.edu/polyq2/ äPolyQ 2 0: an improved version of PolyQ, a database of human polygluta(epmc).pdf DeepDyve Pubget Overpricing