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10.1371/journal.pone.0151252 http://scihub22266oqcxt.onion/10.1371/journal.pone.0151252 C4792482!4792482!26978520     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PLoS+One 2016 ; 11 (3): ä Nephropedia Template TP {{tp|p=26978520|t=2016. Immune Complexes Indirectly Suppress the Generation of Th17 Responses In Vivo |pdf=|usr=}}{{26978520}} gab.com Text Immune Complexes Indirectly Suppress the Generation of Th17 Responses In Vivo JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=26978520 #FOAvip The precise context in which the innate immune system is activated plays a pivotal role in the subsequent instruction of CD4+ T helper (Th) cell responses. Th1 responses are downregulated when antigen is encountered in the presence of antigen-IgG immune complexes. To assess if Th17 responses to antigen are subject to similar influences in the presence of immune complexes we utilized an inflammatory airway disease model in which immunization of mice with Complete Freund?s Adjuvant (CFA) and ovalbumin (Ova) induces a powerful Ova-specific Th1 and Th17 response. Here we show that modification of that immunization with CFA to include IgG-Ova immune complexes results in the suppression of CFA-induced Th17 responses and a concurrent enhancement of Ova-specific Th2 responses. Furthermore, we show the mechanism by which these immune complexes suppress Th17 responses is through the enhancement of IL-10 production. In addition, the generation of Th17 responses following immunization with CFA and Ova were dependent on IL-1? but independent of NLRP3 inflammasome activation. Together these data represent a novel mechanism by which the generation of Th17 responses is regulated. Twit Text FOAVip Immune Complexes Indirectly Suppress the Generation of Th17 Responses In Vivo ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=26978520 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26978520 #FOAvip English Wikipedia <ref>{{Cite pmid|26978520}}</ref> Immune Complexes Indirectly Suppress the Generation of Th17 Responses In Vivo #MMPMID26978520 Ciraci C; Janczy JR; Jain N; Haasken S; Pecli e Silva C; Benjamim CF; Sadler JJ; Olivier AK; Iwakura Y; Shayakhmetov DM; Sutterwala FS; Cassel SL PLoS One 2016[]; 11 (3): ä PMID26978520show ga The precise context in which the innate immune system is activated plays a pivotal role in the subsequent instruction of CD4+ T helper (Th) cell responses. Th1 responses are downregulated when antigen is encountered in the presence of antigen-IgG immune complexes. To assess if Th17 responses to antigen are subject to similar influences in the presence of immune complexes we utilized an inflammatory airway disease model in which immunization of mice with Complete Freund?s Adjuvant (CFA) and ovalbumin (Ova) induces a powerful Ova-specific Th1 and Th17 response. Here we show that modification of that immunization with CFA to include IgG-Ova immune complexes results in the suppression of CFA-induced Th17 responses and a concurrent enhancement of Ova-specific Th2 responses. Furthermore, we show the mechanism by which these immune complexes suppress Th17 responses is through the enhancement of IL-10 production. In addition, the generation of Th17 responses following immunization with CFA and Ova were dependent on IL-1? but independent of NLRP3 inflammasome activation. Together these data represent a novel mechanism by which the generation of Th17 responses is regulated. äImmune Complexes Indirectly Suppress the Generation of Th17 Responses (epmc).pdf DeepDyve Pubget Overpricing