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2015 ; 24
(ä): 170-179
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Novel insights into the role of immune cells in skin and inducible
skin-associated lymphoid tissue (iSALT)
#MMPMID27069837
Ono S
; Kabashima K
Allergo J Int
2015[]; 24
(ä): 170-179
PMID27069837
show ga
The skin is equipped with serial barriers that provide rapid and efficient
protection against external intruders. Beneath the epidermal physical barriers of
the stratum corneum and the tight junctions, the integrated immune systems in
both the epidermis and the dermis act in a coordinated manner to protect the
host. This "immunological" barrier is composed of various cells, including
skin-resident cells, such as keratinocytes, dendritic cells, tissue-resident
macrophages, resident memory T cells, mast cells, and innate lymphoid cells.
Additionally, infiltrating memory T cells, monocytes, neutrophils, basophils, and
eosinophils are recruited in support of the host immunity. In addition to
discussing the role of each of these cellular populations, we describe the
concept of skin associated lymphoid tissue (SALT), which reminds us that the skin
is an important component of the lymphatic system. We further describe the newly
discovered phenomenon of multiple cell gathering under skin inflammation, which
can be referred to as inducible SALT (iSALT). iSALT contributes to our
understanding of SALT by highlighting the importance of direct cell-cell
interaction in skin immunity.