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10.1016/j.immuni.2015.01.020

http://scihub22266oqcxt.onion/10.1016/j.immuni.2015.01.020
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suck abstract from ncbi


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pmid25692699      Immunity 2015 ; 42 (2): 216-26
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  • Emerging functions of amphiregulin in orchestrating immunity, inflammation and tissue repair #MMPMID25692699
  • Zaiss DM; Gause WC; Osborne LC; Artis D
  • Immunity 2015[Feb]; 42 (2): 216-26 PMID25692699show ga
  • Type 2 inflammatory responses can be elicited by diverse stimuli, including toxins, venoms, allergens and infectious agents and play critical roles in resistance and tolerance associated with infection, wound healing, tissue repair and tumor development. Emerging data suggest that in addition to characteristic type 2-associated cytokines, the Epidermal Growth Factor (EGF)-like molecule Amphiregulin (AREG) may be a critical component of type 2-mediated resistance and tolerance. Notably, numerous studies demonstrate that in addition to the established role of epithelial- and mesenchymal-derived AREG, multiple leukocyte populations including mast cells, basophils, group 2 innate lymphoid cells (ILC2) and a subset of tissue-resident regulatory CD4+ T cells can express AREG. In this review, we discuss recent advances in our understanding of the AREG-EGF receptor pathway and its involvement in infection and inflammation, and propose a model for the function of this pathway in the context of resistance and tissue tolerance.
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