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10.1080/23723556.2015.1030536

http://scihub22266oqcxt.onion/10.1080/23723556.2015.1030536
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C4792032!4792032!26989766
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suck abstract from ncbi


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pmid26989766      Mol+Cell+Oncol 2015 ; 2 (4): ä
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  • Novel impact of EWI-2, CD9, and CD81 on TGF-? signaling in melanoma #MMPMID26989766
  • Wang HX; Hemler ME
  • Mol Cell Oncol 2015[Oct]; 2 (4): ä PMID26989766show ga
  • Cell surface transmembrane protein IGFS8 (herein called EWI-2) negatively regulates melanoma TGF-? signaling and is well positioned to control the transition in TGF-? signaling from cytostatic (in early melanoma stages) to pro-invasion/metastasis (in later stages). EWI-2 functions by sequestering the tetraspanin proteins CD9 and CD81, thereby making them unavailable to support the association of TGF? receptor 1 with TGF? receptor 2.
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