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Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Mol+Cell+Oncol 2015 ; 2 (4): ä Nephropedia Template TP
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Novel impact of EWI-2, CD9, and CD81 on TGF-? signaling in melanoma #MMPMID26989766
Wang HX; Hemler ME
Mol Cell Oncol 2015[Oct]; 2 (4): ä PMID26989766show ga
Cell surface transmembrane protein IGFS8 (herein called EWI-2) negatively regulates melanoma TGF-? signaling and is well positioned to control the transition in TGF-? signaling from cytostatic (in early melanoma stages) to pro-invasion/metastasis (in later stages). EWI-2 functions by sequestering the tetraspanin proteins CD9 and CD81, thereby making them unavailable to support the association of TGF? receptor 1 with TGF? receptor 2.