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Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 J+Exp+Clin+Cancer+Res 2016 ; 35 (ä): ä Nephropedia Template TP
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MicroRNA-203 suppresses gastric cancer growth by targeting PIBF1/Akt signaling #MMPMID26980572
Chu SJ; Wang G; Zhang PF; Zhang R; Huang YX; Lu YM; Da W; Sun Q; Zhang J; Zhu JS
J Exp Clin Cancer Res 2016[]; 35 (ä): ä PMID26980572show ga
Background: MicroRNAs (miRNAs) have been proved involved in many tumorigenic behaviors including tumor growth. But, the clinical significance and functions of miRNA-203 in gastric cancer (GC) remain elusive. Results: Decreased expression of miRNA-203 was correlated with tumor size, poor prognosis and recurrence in GC patients. Overexpression of miR-203 or knockdown of its target progesterone immunomodulatory binding factor 1 (PIBF1) inhibited GC growth in vitro and in vivo, while miR-203 knockdown promoted GC proliferation. In addition, PIBF1 overexpression attenuated the inhibitory effects of miR-203 on GC growth and enhanced that effect on p-Akt expression. Conclusions: MiR-203 as a tumor biomarker suppresses GC growth through targeting the PIBF1/Akt signaling, suggesting that it may have the important therapeutic potential for the treatment of GC. Electronic supplementary material: The online version of this article (doi:10.1186/s13046-016-0323-1) contains supplementary material, which is available to authorized users.