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10.1007/s11011-015-9776-8

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suck abstract from ncbi


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pmid26686677
      Metab+Brain+Dis 2016 ; 31 (2 ): 405-15
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  • Optical coherence tomography and electrophysiology of retinal and visual pathways in Wilson s disease #MMPMID26686677
  • Langwi?ska-Wo?ko E ; Litwin T ; Szulborski K ; Cz?onkowska A
  • Metab Brain Dis 2016[Apr]; 31 (2 ): 405-15 PMID26686677 show ga
  • We evaluated correlations between positive findings of changes on brain magnetic resonance imaging (MRI) and selected morphological and electrophysiological parameters of the retinal and visual systems in Wilson's disease. Fifty-eight Wilson's disease symptomatic patients were divided according to whether they displayed brain changes on MRI (positive, n = 39; negative, n = 19). All participants and healthy control group (n = 30), underwent retinal optical coherence tomography to assess the thickness of macula and the total retinal nerve fiber layer. Visual evoked potentials were measured and electroretinography was performed. Macular and retinal nerve fibers were thinner in participants with changes on MRI than in participants without changes. Electrophysiological parameters were markedly different in the MRI positive group compared with the negative group and 30 healthy controls; however, some abnormalities were evident in cases without visible brain pathology. Morphological and electrophysiological changes of retinal and visual pathways are associated with MRI visualized brain injury in Wilson's disease and may be useful for detecting the degree of neurodegeneration.
  • |Evoked Potentials, Visual/*physiology [MESH]
  • |Female [MESH]
  • |Hepatolenticular Degeneration/pathology/*physiopathology [MESH]
  • |Humans [MESH]
  • |Male [MESH]
  • |Nerve Fibers/physiology [MESH]
  • |Retina/*physiopathology [MESH]
  • |Tomography, Optical Coherence/methods [MESH]


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