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10.2486/indhealth.2014-0250

http://scihub22266oqcxt.onion/10.2486/indhealth.2014-0250
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C4791297!4791297!26423330
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suck abstract from ncbi


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pmid26423330      Ind+Health 2016 ; 54 (1): 79-86
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  • Relations of biomarkers of manganese exposure and neuropsychological effects among welders and ferroalloy smelters #MMPMID26423330
  • HASSANI H; GOLBABAEI F; SHIRKHANLOO H; TEHRANI-DOUST M
  • Ind Health 2016[Jan]; 54 (1): 79-86 PMID26423330show ga
  • The objective of present study was to assess relationship between biomarkers of Manganese (Mn) and neuropsychological effects. The study was carried out on 27 welders and 31 ferroalloy smelters as Mn-exposed groups and 30 office workers as unexposed controls. Air Mn concentrations were determined according to NIOSH method 7300. The biological samples were prepared using microwave assisted acid digestion and all samples were analyzed by graphite furnace- atomic absorption spectroscopy (GF-AAS) in order to determine manganese. Questionnaire 16 (Q16) and Cambridge Neuropsychological Test Automated Battery (CANTAB) were used to evaluate the neuropsychological effects. The mean concentrations of air Mn for the welder and ferroalloy smelter groups were 0.023 ± 0.012?mg/m3 and 0.008 ± 0.005?mg/m3, respectively. Manganese concentrations in blood, urine, and toenail samples of exposed workers ranged between 1.80?32.60 (µg/l), 1.00?42.50 (µg/l), and 0.10?6.08 (µg/g), respectively. Mean Mn concentrations in all biological samples of cases were significantly higher than unexposed controls (p<0.05). A moderate relationship was observed between biomarkers of Mn exposure, air Mn, Q16 as well as some neurocognitive outcome measures. The present study shows that blood Mn, urine Mn and toenail Mn could be used to distinguish Mn-exposed workers from unexposed population at the group level.
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