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2016 ; 54
(1
): 79-86
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gab.com Text
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Relations of biomarkers of manganese exposure and neuropsychological effects
among welders and ferroalloy smelters
#MMPMID26423330
Hassani H
; Golbabaei F
; Shirkhanloo H
; Tehrani-Doust M
Ind Health
2016[]; 54
(1
): 79-86
PMID26423330
show ga
The objective of present study was to assess relationship between biomarkers of
Manganese (Mn) and neuropsychological effects. The study was carried out on 27
welders and 31 ferroalloy smelters as Mn-exposed groups and 30 office workers as
unexposed controls. Air Mn concentrations were determined according to NIOSH
method 7300. The biological samples were prepared using microwave assisted acid
digestion and all samples were analyzed by graphite furnace- atomic absorption
spectroscopy (GF-AAS) in order to determine manganese. Questionnaire 16 (Q16) and
Cambridge Neuropsychological Test Automated Battery (CANTAB) were used to
evaluate the neuropsychological effects. The mean concentrations of air Mn for
the welder and ferroalloy smelter groups were 0.023 ± 0.012?mg/m(3) and 0.008 ±
0.005?mg/m(3), respectively. Manganese concentrations in blood, urine, and
toenail samples of exposed workers ranged between 1.80-32.60 (µg/l), 1.00-42.50
(µg/l), and 0.10-6.08 (µg/g), respectively. Mean Mn concentrations in all
biological samples of cases were significantly higher than unexposed controls
(p<0.05). A moderate relationship was observed between biomarkers of Mn exposure,
air Mn, Q16 as well as some neurocognitive outcome measures. The present study
shows that blood Mn, urine Mn and toenail Mn could be used to distinguish
Mn-exposed workers from unexposed population at the group level.