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http://scihub22266oqcxt.onion/ C4791242!4791242!26528856     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncotarget 2015 ; 6 (41): 43438-51 Nephropedia Template TP {{tp|p=26528856|t=2015. Collective cancer cell invasion induced by coordinated contractile stresses |pdf=|usr=}}{{26528856}} gab.com Text Collective cancer cell invasion induced by coordinated contractile stresses JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=26528856 #FOAvip The physical underpinnings of fibrosarcoma cell dissemination from a tumor in a surrounding collagen-rich matrix are poorly understood. Here we show that a tumor spheroid embedded in a 3D collagen matrix exerts large contractile forces on the matrix before invasion. Cell invasion is accompanied by complex spatially and temporally dependent patterns of cell migration within and at the surface of the spheroids that are fundamentally different from migratory patterns of individual fibrosarcoma cells homogeneously distributed in the same type of matrix. Cells display a continuous transition from a round morphology at the spheroid core, to highly aligned elongated morphology at the spheroid periphery, which depends on both ?1-integrin-based cell-matrix adhesion and myosin II/ROCK-based cell contractility. This isotropic-to-anisotropic transition corresponds to a shift in migration, from a slow and unpolarized movement at the core, to a fast, polarized and persistent one at the periphery. Our results also show that the ensuing collective invasion of fibrosarcoma cells is induced by anisotropic contractile stresses exerted on the surrounding matrix. Twit Text FOAVip Collective cancer cell invasion induced by coordinated contractile stresses ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=26528856 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26528856 #FOAvip English Wikipedia <ref>{{Cite pmid|26528856}}</ref> Collective cancer cell invasion induced by coordinated contractile stresses #MMPMID26528856 Valencia AMJ; Wu PH; Yogurtcu ON; Rao P; DiGiacomo J; Godet I; He L; Lee MH; Gilkes D; Sun SX; Wirtz D Oncotarget 2015[Dec]; 6 (41): 43438-51 PMID26528856show ga The physical underpinnings of fibrosarcoma cell dissemination from a tumor in a surrounding collagen-rich matrix are poorly understood. Here we show that a tumor spheroid embedded in a 3D collagen matrix exerts large contractile forces on the matrix before invasion. Cell invasion is accompanied by complex spatially and temporally dependent patterns of cell migration within and at the surface of the spheroids that are fundamentally different from migratory patterns of individual fibrosarcoma cells homogeneously distributed in the same type of matrix. Cells display a continuous transition from a round morphology at the spheroid core, to highly aligned elongated morphology at the spheroid periphery, which depends on both ?1-integrin-based cell-matrix adhesion and myosin II/ROCK-based cell contractility. This isotropic-to-anisotropic transition corresponds to a shift in migration, from a slow and unpolarized movement at the core, to a fast, polarized and persistent one at the periphery. Our results also show that the ensuing collective invasion of fibrosarcoma cells is induced by anisotropic contractile stresses exerted on the surrounding matrix. äCollective cancer cell invasion induced by coordinated contractile str(epmc).pdf DeepDyve Pubget Overpricing