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10.1091/mbc.E15-07-0527

http://scihub22266oqcxt.onion/10.1091/mbc.E15-07-0527
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C4791125!4791125!26823016
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suck abstract from ncbi


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pmid26823016      Mol+Biol+Cell 2016 ; 27 (6): 1040-50
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  • Regulatory roles of conserved phosphorylation sites in the activation T-loop of the MAP kinase ERK1 #MMPMID26823016
  • Lai S; Pelech S
  • Mol Biol Cell 2016[Mar]; 27 (6): 1040-50 PMID26823016show ga
  • Phosphorylation of two highly conserved phosphosites preceding the kinase catalytic subdomain VIII region in the activation T-loop of the MAP kinase ERK1 negatively regulates its protein phosphotransferase activity. Hyperphosphorylation of most protein-serine/threonine kinases in this manner may be a general mechanism for their down-regulation.
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