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10.1126/scisignal.2000230 http://scihub22266oqcxt.onion/10.1126/scisignal.2000230 C4790753!4790753!19471023     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Signal 2009 ; 2 (72): ra25 Nephropedia Template TP {{tp|p=19471023|t=2009. Bruton?s Tyrosine Kinase Revealed as a Negative Regulator of Wnt??-Catenin Signaling |pdf=|usr=}}{{19471023}} gab.com Text Bruton s Tyrosine Kinase Revealed as a Negative Regulator of Wnt -Catenin Signaling JO: Sci Signal http://www.kidney.de/pget.php?&tw=1&pmid=19471023 #FOAvip Wnts are secreted ligands that activate several receptor-mediated signal transduction cascades. Homeostatic Wnt signaling through ?-catenin is required in adults, because either elevation or attenuation of ?-catenin function has been linked to diverse diseases. To contribute to the identification of both protein and pharmacological regulators of this pathway, we describe a combinatorial screen that merged data from a high-throughput screen of known bioactive compounds with an independent focused small interfering RNA screen. Each screen independently revealed Bruton?s tyrosine kinase (BTK) as an inhibitor of Wnt??-catenin signaling. Loss of BTK function in human colorectal cancer cells, human B cells, zebrafish embryos, and cells derived from X-linked agammaglobulinemia patients with a mutant BTK gene resulted in elevated Wnt??-catenin signaling, confirming that BTK acts as a negative regulator of this pathway. From affinity purification?mass spectrometry and biochemical binding studies, we found that BTK directly interacts with a nuclear component of Wnt??-catenin signaling, CDC73. Further, we show that BTK increased the abundance of CDC73 in the absence of stimulation and that CDC73 acted as a repressor of ?-catenin-mediated transcription in human colorectal cancer cells and B cells. Twit Text FOAVip Bruton s Tyrosine Kinase Revealed as a Negative Regulator of Wnt -Catenin Signaling ????Sci Signal http://www.kidney.de/pget.php?&tw=1&pmid=19471023 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=19471023 #FOAvip English Wikipedia <ref>{{Cite pmid|19471023}}</ref> Bruton?s Tyrosine Kinase Revealed as a Negative Regulator of Wnt??-Catenin Signaling #MMPMID19471023 James RG; Biechele TL; Conrad WH; Camp ND; Fass DM; Major MB; Sommer K; Yi X; Roberts BS; Cleary MA; Arthur WT; MacCoss M; Rawlings DJ; Haggarty SJ; Moon RT Sci Signal 2009[]; 2 (72): ra25 PMID19471023show ga Wnts are secreted ligands that activate several receptor-mediated signal transduction cascades. Homeostatic Wnt signaling through ?-catenin is required in adults, because either elevation or attenuation of ?-catenin function has been linked to diverse diseases. To contribute to the identification of both protein and pharmacological regulators of this pathway, we describe a combinatorial screen that merged data from a high-throughput screen of known bioactive compounds with an independent focused small interfering RNA screen. Each screen independently revealed Bruton?s tyrosine kinase (BTK) as an inhibitor of Wnt??-catenin signaling. Loss of BTK function in human colorectal cancer cells, human B cells, zebrafish embryos, and cells derived from X-linked agammaglobulinemia patients with a mutant BTK gene resulted in elevated Wnt??-catenin signaling, confirming that BTK acts as a negative regulator of this pathway. From affinity purification?mass spectrometry and biochemical binding studies, we found that BTK directly interacts with a nuclear component of Wnt??-catenin signaling, CDC73. Further, we show that BTK increased the abundance of CDC73 in the absence of stimulation and that CDC73 acted as a repressor of ?-catenin-mediated transcription in human colorectal cancer cells and B cells. äBruton?s Tyrosine Kinase Revealed as a Negative Regulator of Wnt??-Cat(epmc).pdf DeepDyve Pubget Overpricing