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10.1016/j.neubiorev.2016.01.001 http://scihub22266oqcxt.onion/10.1016/j.neubiorev.2016.01.001 C4790729!4790729!26780584     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Neurosci+Biobehav+Rev 2016 ; 63 (ä): 207-22 Nephropedia Template TP {{tp|p=26780584|t=2016. The Therapeutic Potential of Insulin-Like Growth Factor-1 in Central Nervous System Disorders |pdf=|usr=}}{{26780584}} gab.com Text The Therapeutic Potential of Insulin-Like Growth Factor-1 in Central Nervous System Disorders JO: Neurosci Biobehav Rev http://www.kidney.de/pget.php?&tw=1&pmid=26780584 #FOAvip Central nervous system (CNS) development is a finely tuned process that relies on multiple factors and intricate pathways to ensure proper neuronal differentiation, maturation, and connectivity. Disruption of this process can cause significant impairments in CNS functioning and lead to debilitating disorders that impact motor and language skills, behavior, and cognitive functioning. Recent studies focused on understanding the underlying cellular mechanisms of neurodevelopmental disorders have identified a crucial role for insulin-like growth factor-1 (IGF-1) in normal CNS development. Work in model systems has demonstrated rescue of pathophysiological and behavioral abnormalities when IGF-1 is administered, and several clinical studies have shown promise of efficacy in disorders of the CNS, including autism spectrum disorder (ASD). In this review, we explore the molecular pathways and downstream effects of IGF-1 and summarize the results of completed and ongoing pre-clinical and clinical trials using IGF-1 as a pharmacologic intervention in various CNS disorders. This aim of this review is to provide evidence for the potential of IGF-1 as a treatment for neurodevelopmental disorders and ASD. Twit Text FOAVip The Therapeutic Potential of Insulin-Like Growth Factor-1 in Central Nervous System Disorders ????Neurosci Biobehav Rev http://www.kidney.de/pget.php?&tw=1&pmid=26780584 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26780584 #FOAvip English Wikipedia <ref>{{Cite pmid|26780584}}</ref> The Therapeutic Potential of Insulin-Like Growth Factor-1 in Central Nervous System Disorders #MMPMID26780584 Costales J; Kolevzon A Neurosci Biobehav Rev 2016[Apr]; 63 (ä): 207-22 PMID26780584show ga Central nervous system (CNS) development is a finely tuned process that relies on multiple factors and intricate pathways to ensure proper neuronal differentiation, maturation, and connectivity. Disruption of this process can cause significant impairments in CNS functioning and lead to debilitating disorders that impact motor and language skills, behavior, and cognitive functioning. Recent studies focused on understanding the underlying cellular mechanisms of neurodevelopmental disorders have identified a crucial role for insulin-like growth factor-1 (IGF-1) in normal CNS development. Work in model systems has demonstrated rescue of pathophysiological and behavioral abnormalities when IGF-1 is administered, and several clinical studies have shown promise of efficacy in disorders of the CNS, including autism spectrum disorder (ASD). In this review, we explore the molecular pathways and downstream effects of IGF-1 and summarize the results of completed and ongoing pre-clinical and clinical trials using IGF-1 as a pharmacologic intervention in various CNS disorders. This aim of this review is to provide evidence for the potential of IGF-1 as a treatment for neurodevelopmental disorders and ASD. äThe Therapeutic Potential of Insulin-Like Growth Factor-1 in Central N(epmc).pdf DeepDyve Pubget Overpricing