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10.2147/IJNRD.S89704

http://scihub22266oqcxt.onion/10.2147/IJNRD.S89704
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C4790490!4790490!27022297
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suck abstract from ncbi


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pmid27022297      Int+J+Nephrol+Renovasc+Dis 2016 ; 9 (ä): 53-64
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  • Efficacy and safety of iron isomaltoside (Monofer®) in the management of patients with iron deficiency anemia #MMPMID27022297
  • Kalra PA; Bhandari S
  • Int J Nephrol Renovasc Dis 2016[]; 9 (ä): 53-64 PMID27022297show ga
  • New intravenous (IV) iron preparations should ideally be capable of delivering a wide dosing range to allow iron correction in a single or low number of visits, a rapid infusion (doses up to 1,000 mg must be administered over more than 15 minutes and doses exceeding 1,000 mg must be administered over 30 minutes or more), and minimal potential side effects including low catalytic/labile iron release with minimal risk of anaphylaxis. Furthermore, they should be convenient for the patient and health-care professional, and cost effective for the health-care system. The intention behind the development of iron isomaltoside (Monofer®) was to fulfill these requirements. Iron isomaltoside has been shown to be effective in treating iron deficiency anemia across multiple therapeutic patient groups and compared to placebo, IV iron sucrose, and oral iron. Iron isomaltoside consists of iron and a carbohydrate moiety where the iron is tightly bound in a matrix structure. It has a low immunogenic potential, a low potential to release labile iron, and does not appear to be associated with clinically significant hypophosphatemia. Due to the structure of iron isomaltoside, it can be administered in high doses with a maximum single dosage of 20 mg/kg body weight. Clinical trials and observational studies of iron isomaltoside show that it is an effective and well-tolerated treatment of anemia across different therapeutic areas with a favorable safety profile.
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