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2016 ; 9
(ä): 53-64
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Efficacy and safety of iron isomaltoside (Monofer(®)) in the management of
patients with iron deficiency anemia
#MMPMID27022297
Kalra PA
; Bhandari S
Int J Nephrol Renovasc Dis
2016[]; 9
(ä): 53-64
PMID27022297
show ga
New intravenous (IV) iron preparations should ideally be capable of delivering a
wide dosing range to allow iron correction in a single or low number of visits, a
rapid infusion (doses up to 1,000 mg must be administered over more than 15
minutes and doses exceeding 1,000 mg must be administered over 30 minutes or
more), and minimal potential side effects including low catalytic/labile iron
release with minimal risk of anaphylaxis. Furthermore, they should be convenient
for the patient and health-care professional, and cost effective for the
health-care system. The intention behind the development of iron isomaltoside
(Monofer(®)) was to fulfill these requirements. Iron isomaltoside has been shown
to be effective in treating iron deficiency anemia across multiple therapeutic
patient groups and compared to placebo, IV iron sucrose, and oral iron. Iron
isomaltoside consists of iron and a carbohydrate moiety where the iron is tightly
bound in a matrix structure. It has a low immunogenic potential, a low potential
to release labile iron, and does not appear to be associated with clinically
significant hypophosphatemia. Due to the structure of iron isomaltoside, it can
be administered in high doses with a maximum single dosage of 20 mg/kg body
weight. Clinical trials and observational studies of iron isomaltoside show that
it is an effective and well-tolerated treatment of anemia across different
therapeutic areas with a favorable safety profile.