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10.3390/antibiotics1010001 http://scihub22266oqcxt.onion/10.3390/antibiotics1010001 C4790241!4790241!27029415     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Antibiotics+(Basel) 2012 ; 1 (1): 1-13 Nephropedia Template TP {{tp|p=27029415|t=2012. Classification Framework and Chemical Biology of Tetracycline-Structure-Based Drugs |pdf=|usr=}}{{27029415}} gab.com Text Classification Framework and Chemical Biology of Tetracycline-Structure-Based Drugs JO: Antibiotics (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=27029415 #FOAvip By studying the literature about tetracyclines (TCs), it becomes clearly evident that TCs are very dynamic molecules. In some cases, their structure-activity-relationship (SAR) are well known, especially against bacteria, while against other targets, they are virtually unknown. In other diverse fields of research?such as neurology, oncology and virology?the utility and activity of the tetracyclines are being discovered and are also emerging as new technological fronts. The first aim of this paper is to classify the compounds already used in therapy and prepare the schematic structure that includes the next generation of TCs. The second aim of this work is to introduce a new framework for the classification of old and new TCs, using a medicinal chemistry approach to the structure of those drugs. A fully documented Structure-Activity-Relationship (SAR) is presented with the analysis data of antibacterial and nonantibacterial (antifungal, antiviral and anticancer) tetracyclines. The lipophilicity and the conformational interchangeability of the functional groups are employed to develop the rules for TC biological activity. Twit Text FOAVip Classification Framework and Chemical Biology of Tetracycline-Structure-Based Drugs ????Antibiotics (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=27029415 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27029415 #FOAvip English Wikipedia <ref>{{Cite pmid|27029415}}</ref> Classification Framework and Chemical Biology of Tetracycline-Structure-Based Drugs #MMPMID27029415 Fuoco D Antibiotics (Basel) 2012[Dec]; 1 (1): 1-13 PMID27029415show ga By studying the literature about tetracyclines (TCs), it becomes clearly evident that TCs are very dynamic molecules. In some cases, their structure-activity-relationship (SAR) are well known, especially against bacteria, while against other targets, they are virtually unknown. In other diverse fields of research?such as neurology, oncology and virology?the utility and activity of the tetracyclines are being discovered and are also emerging as new technological fronts. The first aim of this paper is to classify the compounds already used in therapy and prepare the schematic structure that includes the next generation of TCs. The second aim of this work is to introduce a new framework for the classification of old and new TCs, using a medicinal chemistry approach to the structure of those drugs. A fully documented Structure-Activity-Relationship (SAR) is presented with the analysis data of antibacterial and nonantibacterial (antifungal, antiviral and anticancer) tetracyclines. The lipophilicity and the conformational interchangeability of the functional groups are employed to develop the rules for TC biological activity. äClassification Framework and Chemical Biology of Tetracycline-Structur(epmc).pdf DeepDyve Pubget Overpricing