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10.3389/fonc.2016.00058 http://scihub22266oqcxt.onion/10.3389/fonc.2016.00058 C4790194!4790194!27014633     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Oncol 2016 ; 6 (ä): ä Nephropedia Template TP {{tp|p=27014633|t=2016. Influence of Dose Rate on the Cellular Response to Low- and High-LET Radiations |pdf=|usr=}}{{27014633}} gab.com Text Influence of Dose Rate on the Cellular Response to Low- and High-LET Radiations JO: Front Oncol http://www.kidney.de/pget.php?&tw=1&pmid=27014633 #FOAvip Nowadays, head and neck squamous cell carcinoma (HNSCC) treatment failure is mostly explained by locoregional progression or intrinsic radioresistance. Radiotherapy (RT) has recently evolved with the emergence of heavy ion radiations or new fractionation schemes of photon therapy, which modify the dose rate of treatment delivery. The aim of the present study was then to evaluate the in vitro influence of a dose rate variation during conventional RT or carbon ion hadrontherapy treatment in order to improve the therapeutic care of patient. In this regard, two HNSCC cell lines were irradiated with photons or 72?MeV/n carbon ions at a dose rate of 0.5, 2, or 10?Gy/min. For both radiosensitive and radioresistant cells, the change in dose rate significantly affected cell survival in response to photon exposure. This variation of radiosensitivity was associated with the number of initial and residual DNA double-strand breaks (DSBs). By contrast, the dose rate change did not affect neither cell survival nor the residual DNA DSBs after carbon ion irradiation. As a result, the relative biological efficiency at 10% survival increased when the dose rate decreased. In conclusion, in the RT treatment of HNSCC, it is advised to remain very careful when modifying the classical schemes toward altered fractionation. At the opposite, as the dose rate does not seem to have any effects after carbon ion exposure, there is less need to adapt hadrontherapy treatment planning during active system irradiation. Twit Text FOAVip Influence of Dose Rate on the Cellular Response to Low- and High-LET Radiations ????Front Oncol http://www.kidney.de/pget.php?&tw=1&pmid=27014633 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27014633 #FOAvip English Wikipedia <ref>{{Cite pmid|27014633}}</ref> Influence of Dose Rate on the Cellular Response to Low- and High-LET Radiations #MMPMID27014633 Wozny AS; Alphonse G; Battiston-Montagne P; Simonet S; Poncet D; Testa E; Guy JB; Rancoule C; Magné N; Beuve M; Rodriguez-Lafrasse C Front Oncol 2016[]; 6 (ä): ä PMID27014633show ga Nowadays, head and neck squamous cell carcinoma (HNSCC) treatment failure is mostly explained by locoregional progression or intrinsic radioresistance. Radiotherapy (RT) has recently evolved with the emergence of heavy ion radiations or new fractionation schemes of photon therapy, which modify the dose rate of treatment delivery. The aim of the present study was then to evaluate the in vitro influence of a dose rate variation during conventional RT or carbon ion hadrontherapy treatment in order to improve the therapeutic care of patient. In this regard, two HNSCC cell lines were irradiated with photons or 72?MeV/n carbon ions at a dose rate of 0.5, 2, or 10?Gy/min. For both radiosensitive and radioresistant cells, the change in dose rate significantly affected cell survival in response to photon exposure. This variation of radiosensitivity was associated with the number of initial and residual DNA double-strand breaks (DSBs). By contrast, the dose rate change did not affect neither cell survival nor the residual DNA DSBs after carbon ion irradiation. As a result, the relative biological efficiency at 10% survival increased when the dose rate decreased. In conclusion, in the RT treatment of HNSCC, it is advised to remain very careful when modifying the classical schemes toward altered fractionation. At the opposite, as the dose rate does not seem to have any effects after carbon ion exposure, there is less need to adapt hadrontherapy treatment planning during active system irradiation. äInfluence of Dose Rate on the Cellular Response to Low- and High-LET R(epmc).pdf DeepDyve Pubget Overpricing