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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Nephropathol
2016 ; 5
(1
): 28-33
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Correlation of plasma interleukin-18 concentration and severity of renal
involvement and disease activity in systemic lupus erythematosus
#MMPMID27047807
Jafari-Nakhjavani MR
; Abedi-Azar S
; Nejati B
J Nephropathol
2016[Jan]; 5
(1
): 28-33
PMID27047807
show ga
BACKGROUND: Systemic lupus erythematosus (SLE) is a systemic autoimmune disease
characterized by activation of T and polyclonal B lymphocytes. IL-18 was
originally identified as a factor which enhances IFN-? production and is a potent
inducer of the inflammatory mediators by T cells, causing severe inflammatory
disorders in SLE. OBJECTIVES: This study aimed to evaluate the association of
plasma interlukine-18 (IL-18) concentration and severity of lupus nephritis (LN)
and disease activity in SLE patients. PATIENTS AND METHODS: In this
cross-sectional study, 113 patients with SLE and 50 healthy individuals were
examined. Serum level of IL-18 was measured. The severity and activity of the
disease was determined by Systemic Lupus Erythematosus Disease Activity Index
(SLEDAI) score. The severity of kidney involvement was studied by renal biopsy,
serum creatinine and 24 hours urine protein level. RESULTS: The mean level of
serum IL-18 was significantly higher in the patients than controls (577.67 ±
649.95 versus 60.48 ± 19.53 pg/ml; P < 0.001). In SLE patients with active
disease level of serum IL-18 was significantly higher than chronic disease
(622.77 ± 716.54 versus 182 ± 184.37 pg/ml; P < 0.001). The serum level of IL-18
was significantly higher in stage IV (P < 0.001) and V (P < 0.001) of patients
with LN, than other stages. CONCLUSIONS: The current study showed that the serum
IL-18 is significantly higher in the patients than controls and it significantly
correlated with sever renal involvement and disease activity in SLE patients.