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10.1016/j.it.2014.05.001

http://scihub22266oqcxt.onion/10.1016/j.it.2014.05.001
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C4790094!4790094!24932518
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suck abstract from ncbi

pmid24932518      Trends+Immunol 2014 ; 35 (7): 332-44
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  • Divalent cation signaling in immune cells #MMPMID24932518
  • Chaigne-Delalande B; Lenardo MJ
  • Trends Immunol 2014[Jul]; 35 (7): 332-44 PMID24932518show ga
  • Divalent cations of two alkaline earth metals Ca2+ and Mg2+ and the transition metal Zn2+ play vital roles in the immune system, and several immune disorders are associated with disturbances of their function. Until recently, only Ca2+ was considered to serve as a second messenger. However, signaling roles for Mg2+ and Zn2+ have been recently described, leading to a reevaluation of their role as potential second messengers. Here we review the roles of these cations as second messengers in light of recent advances in Ca2+, Mg2+ and Zn2+ signaling in the immune system. Developing a better understanding of these signaling cations may lead to new therapeutic strategies for immune disorders.
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