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2016 ; 6
(2
): 143-9
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English Wikipedia
Prognostic Implications of Acute Renal Impairment among ST Elevation Myocardial
Infarction Patients with Preserved Left Ventricular Function
#MMPMID26989399
Shacham Y
; Gal-Oz A
; Ben-Shoshan J
; Keren G
; Arbel Y
Cardiorenal Med
2016[Feb]; 6
(2
): 143-9
PMID26989399
show ga
BACKGROUND: Only limited data is present regarding the incidence and prognostic
implications of acute kidney injury (AKI) in ST elevation myocardial infarction
(STEMI) patients with preserved left ventricular (LV) function in the primary
percutaneous coronary intervention (PCI) era. METHODS: We conducted a
retrospective study of 842 consecutive STEMI patients with preserved LV function
(ejection fraction ?50%, assessed by echocardiography) who underwent primary PCI
between January 2008 and January 2015. AKI was defined as an increase of ?0.3
mg/dl in serum creatinine within 48 h following admission. Patients were assessed
for all-cause mortality up to 5 years. RESULTS: Fifty-two patients (6.2%)
developed AKI. Patients with AKI were older, had impaired baseline renal
function, and presented more often with heart failure throughout their
hospitalization. Patients with AKI had a higher 5-year all-cause mortality (13.4
vs. 2.4%, p < 0.001). Compared to patients with no AKI, the adjusted hazard ratio
for all-cause mortality was 2.64 (95% CI 1.25-5.56, p = 0.01). CONCLUSIONS: Among
STEMI patients with preserved LV function undergoing primary PCI, AKI is
associated with a higher long-term mortality.