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2016 ; 28
(1
): 53-6
Nephropedia Template TP
gab.com Text
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English Wikipedia
CONTRIBUTING FACTORS FOR DEVELOPMENT OF NECROTIZING ENTEROCOLITIS IN PRETERM
INFANTS IN THE NEONATAL INTENSIVE CARE UNIT
#MMPMID27047269
Zvizdic Z
; Heljic S
; Popovic N
; Alajbegovic-Halimic J
; Milisic E
; Jonuzi A
Mater Sociomed
2016[Feb]; 28
(1
): 53-6
PMID27047269
show ga
BACKGROUND: necrotizing enterocolitis is a serious condition that affects mostly
preterm infants, with high mortality rate. AIM: to estimate the influence of
potentially contributing factors of this multifactorial disease. METHODS: the
study group included 51 necrotizing enterocolitis infants who were less than 37
week gestation who were hospitalized in NICU during a five year period. The
control group consisted of 71 patients with approximately the same gestational
age and birth weight. Average gestational age in the study group was 30.2 weeks
(SD 3.7), average birth weight 1502g (SD 781.5). Average postnatal age in the
time of the presenting NEC was 18.2 days (SD 12.8). RESULTS: Logistic regression
estimates the influence of risk factors, which in our study related to the
treatment of preterm infants on the likelihood of NEC development. Our regression
model consisted of seven independent variables (nosocomial infections, mechanical
ventilation, nasal continuous positive pressure, morphine, inotropes, blood
transfusions, and H2 blockers), which were shown to have a statistically
significant impact, X2 (7, n=1222) = 49.522, p<0.0001; two independent variables
(nosocomial infection and H2 blockers use) were statistically significant.
Preterm infants with nosocomial infection had a three times greater chance of
developing NEC, and infants who received H2 blockers had a 1.5 higher risk.
CONCLUSIONS: Underlying pathology of very low birth weight infants and their
treatment in NICU contribute to NEC development. Identifying risk factors can be
crucial for the early diagnosis and outcome of disease. Awareness of risk factors
should influence changes in practice to reduce the risk of NEC.