Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1136/annrheumdis-2014-206914 http://scihub22266oqcxt.onion/10.1136/annrheumdis-2014-206914 C4789700!4789700!25732175     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Ann+Rheum+Dis 2016 ; 75 (3): 552-9 Nephropedia Template TP {{tp|p=25732175|t=2016. Paracetamol: not as safe as we thought? A systematic literature review of observational studies |pdf=|usr=}}{{25732175}} gab.com Text Paracetamol: not as safe as we thought A systematic literature review of observational studies JO: Ann Rheum Dis http://www.kidney.de/pget.php?&tw=1&pmid=25732175 #FOAvip Objectives: We conducted a systematic literature review to assess the adverse event (AE) profile of paracetamol. Methods: We searched Medline and Embase from database inception to 1 May 2013. We screened for observational studies in English, which reported mortality, cardiovascular, gastrointestinal (GI) or renal AEs in the general adult population at standard analgesic doses of paracetamol. Study quality was assessed using Grading of Recommendations Assessment, Development and Evaluation. Pooled or adjusted summary statistics were presented for each outcome. Results: Of 1888 studies retrieved, 8 met inclusion criteria, and all were cohort studies. Comparing paracetamol use versus no use, of two studies reporting mortality one showed a dose?response and reported an increased relative rate of mortality from 0.95 (0.92 to 0.98) to 1.63 (1.58 to 1.68). Of four studies reporting cardiovascular AEs, all showed a dose?response with one reporting an increased risk ratio of all cardiovascular AEs from 1.19 (0.81 to 1.75) to 1.68 (1.10 to 2.57). One study reporting GI AEs reported a dose?response with increased relative rate of GI AEs or bleeds from 1.11 (1.04 to 1.18) to 1.49 (1.34 to 1.66). Of four studies reporting renal AEs, three reported a dose?response with one reporting an increasing OR of ?30% decrease in estimated glomerular filtration rate from 1.40 (0.79 to 2.48) to 2.19 (1.4 to 3.43). Discussion: Given the observational nature of the data, channelling bias may have had an important impact. However, the dose?response seen for most endpoints suggests a considerable degree of paracetamol toxicity especially at the upper end of standard analgesic doses. Twit Text FOAVip Paracetamol: not as safe as we thought A systematic literature review of observational studies ????Ann Rheum Dis http://www.kidney.de/pget.php?&tw=1&pmid=25732175 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25732175 #FOAvip English Wikipedia <ref>{{Cite pmid|25732175}}</ref> Paracetamol: not as safe as we thought? A systematic literature review of observational studies #MMPMID25732175 Roberts E; Delgado Nunes V; Buckner S; Latchem S; Constanti M; Miller P; Doherty M; Zhang W; Birrell F; Porcheret M; Dziedzic K; Bernstein I; Wise E; Conaghan PG Ann Rheum Dis 2016[Mar]; 75 (3): 552-9 PMID25732175show ga Objectives: We conducted a systematic literature review to assess the adverse event (AE) profile of paracetamol. Methods: We searched Medline and Embase from database inception to 1 May 2013. We screened for observational studies in English, which reported mortality, cardiovascular, gastrointestinal (GI) or renal AEs in the general adult population at standard analgesic doses of paracetamol. Study quality was assessed using Grading of Recommendations Assessment, Development and Evaluation. Pooled or adjusted summary statistics were presented for each outcome. Results: Of 1888 studies retrieved, 8 met inclusion criteria, and all were cohort studies. Comparing paracetamol use versus no use, of two studies reporting mortality one showed a dose?response and reported an increased relative rate of mortality from 0.95 (0.92 to 0.98) to 1.63 (1.58 to 1.68). Of four studies reporting cardiovascular AEs, all showed a dose?response with one reporting an increased risk ratio of all cardiovascular AEs from 1.19 (0.81 to 1.75) to 1.68 (1.10 to 2.57). One study reporting GI AEs reported a dose?response with increased relative rate of GI AEs or bleeds from 1.11 (1.04 to 1.18) to 1.49 (1.34 to 1.66). Of four studies reporting renal AEs, three reported a dose?response with one reporting an increasing OR of ?30% decrease in estimated glomerular filtration rate from 1.40 (0.79 to 2.48) to 2.19 (1.4 to 3.43). Discussion: Given the observational nature of the data, channelling bias may have had an important impact. However, the dose?response seen for most endpoints suggests a considerable degree of paracetamol toxicity especially at the upper end of standard analgesic doses. äParacetamol: not as safe as we thought? A systematic literature review(epmc).pdf DeepDyve Pubget Overpricing