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10.1136/annrheumdis-2014-206897 http://scihub22266oqcxt.onion/10.1136/annrheumdis-2014-206897 C4789692!4789692 !25757867     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25757867 &cmd=llinks): Failed to open stream: HTTP request failed! 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Long-term follow-up of the MAINTAIN Nephritis Trial, comparing azathioprine and mycophenolate mofetil as maintenance therapy of lupus nephritis |pdf=|usr=}}{{25757867 }} gab.com Text Long-term follow-up of the MAINTAIN Nephritis Trial, comparing azathioprine and mycophenolate mofetil as maintenance therapy of lupus nephritis JO: Ann Rheum Dis http://www.kidney.de/pget.php?&tw=1&pmid=25757867 #FOAvip OBJECTIVE: To report the 10-year follow-up of the MAINTAIN Nephritis Trial comparing azathioprine (AZA) and mycophenolate mofetil (MMF) as maintenance therapy of proliferative lupus nephritis, and to test different definitions of early response as predictors of long-term renal outcome. METHODS: In 2014, data on survival, kidney function, 24?h proteinuria, renal flares and other outcomes were collected for the 105 patients randomised between 2002 and 2006, except in 13 lost to follow-up. RESULTS: Death (2 and 3 in the AZA and MMF groups, respectively) and end-stage renal disease (1 and 3, respectively) were rare events. Time to renal flare (22 and 19 flares in AZA and MMF groups, respectively) did not differ between AZA and MMF patients. Patients with good long-term renal outcome had a much more stringent early decrease of 24?h proteinuria compared with patients with poor outcome. The positive predictive value of a 24?h proteinuria <0.5?g/day at 3 months, 6 months and 12?months for a good long-term renal outcome was excellent (between 89% and 92%). Inclusion of renal function and urinalysis in the early response criteria did not impact the value of early proteinuria decrease as long-term prognostic marker. CONCLUSIONS: The long-term follow-up data of the MAINTAIN Nephritis Trial do not indicate that MMF is superior to AZA as maintenance therapy in a Caucasian population suffering from proliferative lupus nephritis. Moreover, we confirm the excellent positive predictive value of an early proteinuria decrease for long-term renal outcome. TRIAL REGISTRATION NUMBER: NCT00204022. Twit Text FOAVip Long-term follow-up of the MAINTAIN Nephritis Trial, comparing azathioprine and mycophenolate mofetil as maintenance therapy of lupus nephritis ????Ann Rheum Dis http://www.kidney.de/pget.php?&tw=1&pmid=25757867 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25757867 #FOAvip English Wikipedia <ref>{{Cite pmid|25757867 }}</ref> Long-term follow-up of the MAINTAIN Nephritis Trial, comparing azathioprine and mycophenolate mofetil as maintenance therapy of lupus nephritis #MMPMID25757867 Tamirou F ; D'Cruz D ; Sangle S ; Remy P ; Vasconcelos C ; Fiehn C ; Ayala Guttierez Mdel M ; Gilboe IM ; Tektonidou M ; Blockmans D ; Ravelingien I ; le Guern V ; Depresseux G ; Guillevin L ; Cervera R ; Houssiau FA Ann Rheum Dis 2016[Mar]; 75 (3 ): 526-31 PMID25757867 show ga OBJECTIVE: To report the 10-year follow-up of the MAINTAIN Nephritis Trial comparing azathioprine (AZA) and mycophenolate mofetil (MMF) as maintenance therapy of proliferative lupus nephritis, and to test different definitions of early response as predictors of long-term renal outcome. METHODS: In 2014, data on survival, kidney function, 24?h proteinuria, renal flares and other outcomes were collected for the 105 patients randomised between 2002 and 2006, except in 13 lost to follow-up. RESULTS: Death (2 and 3 in the AZA and MMF groups, respectively) and end-stage renal disease (1 and 3, respectively) were rare events. Time to renal flare (22 and 19 flares in AZA and MMF groups, respectively) did not differ between AZA and MMF patients. Patients with good long-term renal outcome had a much more stringent early decrease of 24?h proteinuria compared with patients with poor outcome. The positive predictive value of a 24?h proteinuria <0.5?g/day at 3 months, 6 months and 12?months for a good long-term renal outcome was excellent (between 89% and 92%). Inclusion of renal function and urinalysis in the early response criteria did not impact the value of early proteinuria decrease as long-term prognostic marker. CONCLUSIONS: The long-term follow-up data of the MAINTAIN Nephritis Trial do not indicate that MMF is superior to AZA as maintenance therapy in a Caucasian population suffering from proliferative lupus nephritis. Moreover, we confirm the excellent positive predictive value of an early proteinuria decrease for long-term renal outcome. TRIAL REGISTRATION NUMBER: NCT00204022. |Adult [MESH] |Azathioprine/*therapeutic use [MESH] |Disease Progression [MESH] |Female [MESH] |Follow-Up Studies [MESH] |Humans [MESH] |Immunosuppressive Agents/*therapeutic use [MESH] |Kidney Failure, Chronic [MESH] |Longitudinal Studies [MESH] |Lupus Nephritis/*drug therapy [MESH] |Maintenance Chemotherapy [MESH] |Male [MESH] |Middle Aged [MESH] |Mycophenolic Acid/*analogs & derivatives/therapeutic use [MESH] |Proteinuria [MESH]Long-term follow-up of the MAINTAIN Nephritis Trial, comparing azathio(epmc).pdf DeepDyve Pubget Overpricing