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10.1021/acsmedchemlett.5b00452 http://scihub22266oqcxt.onion/10.1021/acsmedchemlett.5b00452 C4789659!4789659!26985319     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       ACS+Med+Chem+Lett 2016 ; 7 (3): 300-5 Nephropedia Template TP {{tp|p=26985319|t=2016. Potent and Selective CK2 Kinase Inhibitors with Effects on Wnt Pathway Signaling in Vivo |pdf=|usr=}}{{26985319}} gab.com Text Potent and Selective CK2 Kinase Inhibitors with Effects on Wnt Pathway Signaling in Vivo JO: ACS Med Chem Lett http://www.kidney.de/pget.php?&tw=1&pmid=26985319 #FOAvip The Wnt pathway is an evolutionarily conserved and tightly regulated signaling network with important roles in embryonic development and adult tissue regeneration. Impaired Wnt pathway regulation, arising from mutations in Wnt signaling components, such as Axin, APC, and ?-catenin, results in uncontrolled cell growth and triggers oncogenesis. To explore the reported link between CK2 kinase activity and Wnt pathway signaling, we sought to identify a potent, selective inhibitor of CK2 suitable for proof of concept studies in vivo. Starting from a pyrazolo[1,5-a]pyrimidine lead (2), we identified compound 7h, a potent CK2 inhibitor with picomolar affinity that is highly selectivity against other kinase family enzymes and inhibits Wnt pathway signaling (IC50 = 50 nM) in DLD-1 cells. In addition, compound 7h has physicochemical properties that are suitable for formulation as an intravenous solution, has demonstrated good pharmacokinetics in preclinical species, and exhibits a high level of activity as a monotherapy in HCT-116 and SW-620 xenografts. Twit Text FOAVip Potent and Selective CK2 Kinase Inhibitors with Effects on Wnt Pathway Signaling in Vivo ????ACS Med Chem Lett http://www.kidney.de/pget.php?&tw=1&pmid=26985319 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26985319 #FOAvip English Wikipedia <ref>{{Cite pmid|26985319}}</ref> Potent and Selective CK2 Kinase Inhibitors with Effects on Wnt Pathway Signaling in Vivo #MMPMID26985319 Dowling JE; Alimzhanov M; Bao L; Chuaqui C; Denz C; Jenkins E; Larsen NA; Lyne PD; Pontz T; Ye Q; Holdgate GA; Snow L; O?Connell N; Ferguson AD ACS Med Chem Lett 2016[Mar]; 7 (3): 300-5 PMID26985319show ga The Wnt pathway is an evolutionarily conserved and tightly regulated signaling network with important roles in embryonic development and adult tissue regeneration. Impaired Wnt pathway regulation, arising from mutations in Wnt signaling components, such as Axin, APC, and ?-catenin, results in uncontrolled cell growth and triggers oncogenesis. To explore the reported link between CK2 kinase activity and Wnt pathway signaling, we sought to identify a potent, selective inhibitor of CK2 suitable for proof of concept studies in vivo. Starting from a pyrazolo[1,5-a]pyrimidine lead (2), we identified compound 7h, a potent CK2 inhibitor with picomolar affinity that is highly selectivity against other kinase family enzymes and inhibits Wnt pathway signaling (IC50 = 50 nM) in DLD-1 cells. In addition, compound 7h has physicochemical properties that are suitable for formulation as an intravenous solution, has demonstrated good pharmacokinetics in preclinical species, and exhibits a high level of activity as a monotherapy in HCT-116 and SW-620 xenografts. äPotent and Selective CK2 Kinase Inhibitors with Effects on Wnt Pathway(epmc).pdf DeepDyve Pubget Overpricing