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2016 ; 8
(3
): 258-70
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gab.com Text
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Primary prevention and treatment of venous thromboembolic events in patients with
gastrointestinal cancers - Review
#MMPMID26989461
Riess H
; Habbel P
; Jühling A
; Sinn M
; Pelzer U
World J Gastrointest Oncol
2016[Mar]; 8
(3
): 258-70
PMID26989461
show ga
Venous thromboembolism event (VTE) is a common and morbid complication in cancer
patients. Patients with gastrointestinal cancers often suffer from symptomatic or
incidental splanchnic vein thrombosis, impaired liver function and/or
thrombocytopenia. These characteristics require a thorough risk/benefit
evaluation for individual patients. Considering the risk factors for the
development of VTE and bleeding events in addition to recent study results may be
helpful for correct initiation of primary pharmacological prevention and
treatment of cancer-associated thrombosis (CAT), preferably with low molecular
weight heparins (LMWH). Whereas thromboprophylaxis is most often recommended in
hospitalized surgical and non-surgical patients with malignancy, there is less
agreement as to its duration. With regard to ambulatory cancer patients, the lack
of robust data results in low grade recommendations against routine use of
anticoagulant drugs. Anticoagulation with LMWH for the first months is the
evidence-based treatment for acute CAT, but duration of secondary prevention and
the drug of choice are unclear. Based on published guidelines and literature,
this review will focus on prevention and treatment strategies of VTE in patients
with gastrointestinal cancers.