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10.1155/2016/2460206

http://scihub22266oqcxt.onion/10.1155/2016/2460206
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C4789414!4789414 !27069296
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suck abstract from ncbi


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pmid27069296
      Dis+Markers 2016 ; 2016 (ä): 2460206
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  • Association of Plasma IL-32 Levels and Gene Polymorphisms with Systemic Lupus Erythematosus in Chinese Han Population #MMPMID27069296
  • Wang Y ; Zhou B ; Zhao Y ; Yu X ; Liu Y ; Zhang L
  • Dis Markers 2016[]; 2016 (ä): 2460206 PMID27069296 show ga
  • Systemic lupus erythematosus (SLE) is a multisystemic autoimmune disease. IL-32, a secreted protein, has been reported to be associated with several autoimmune diseases. Our preliminary experiment showed different plasma IL-32 levels than that mentioned in a published report on the same population. In order to elucidate the correlation between IL-32 and SLE, we determined the plasma level and two single nucleotide polymorphisms (SNPs) of IL-32 in 152 patients with SLE and 310 healthy controls and analyzed the relationship based on the clinical parameters. The results showed that plasma IL-32 levels in patients with SLE were markedly lower than that in the healthy controls. In the SLE group, patients with detectable IL-32 presented low serum C3 concentrations. Further studies indicated that the rs28372698 SNP was associated with the susceptibility to SLE. Taken together, our results suggested that IL-32 could possibly be a candidate marker to monitor SLE disease stability and screening in future.
  • |*Polymorphism, Single Nucleotide [MESH]
  • |Adolescent [MESH]
  • |Adult [MESH]
  • |Asian People/ethnology/*genetics [MESH]
  • |China/ethnology [MESH]
  • |Down-Regulation [MESH]
  • |Female [MESH]
  • |Genetic Association Studies [MESH]
  • |Genetic Predisposition to Disease [MESH]
  • |Humans [MESH]
  • |Interleukins/*blood/*genetics [MESH]
  • |Lupus Erythematosus, Systemic/ethnology/genetics/*immunology [MESH]
  • |Middle Aged [MESH]


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