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2016 ; 2016
(ä): 2460206
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Association of Plasma IL-32 Levels and Gene Polymorphisms with Systemic Lupus
Erythematosus in Chinese Han Population
#MMPMID27069296
Wang Y
; Zhou B
; Zhao Y
; Yu X
; Liu Y
; Zhang L
Dis Markers
2016[]; 2016
(ä): 2460206
PMID27069296
show ga
Systemic lupus erythematosus (SLE) is a multisystemic autoimmune disease. IL-32,
a secreted protein, has been reported to be associated with several autoimmune
diseases. Our preliminary experiment showed different plasma IL-32 levels than
that mentioned in a published report on the same population. In order to
elucidate the correlation between IL-32 and SLE, we determined the plasma level
and two single nucleotide polymorphisms (SNPs) of IL-32 in 152 patients with SLE
and 310 healthy controls and analyzed the relationship based on the clinical
parameters. The results showed that plasma IL-32 levels in patients with SLE were
markedly lower than that in the healthy controls. In the SLE group, patients with
detectable IL-32 presented low serum C3 concentrations. Further studies indicated
that the rs28372698 SNP was associated with the susceptibility to SLE. Taken
together, our results suggested that IL-32 could possibly be a candidate marker
to monitor SLE disease stability and screening in future.