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2016 ; 2016
(ä): 3019410
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Impact of Iodinated Contrast on Renal Function and Hemodynamics in Rats with
Chronic Hyperglycemia and Chronic Kidney Disease
#MMPMID27034930
Fernandes SM
; Martins DM
; da Fonseca CD
; Watanabe M
; Vattimo Mde F
Biomed Res Int
2016[]; 2016
(ä): 3019410
PMID27034930
show ga
Iodinated contrast (IC) is clinically used in diagnostic and interventional
procedures, but its use can result in contrast-induced acute kidney injury
(CI-AKI). Chronic kidney disease (CKD) and chronic hyperglycemia (CH) are
important predisposing factors to CI-AKI. The aim of this study was to
investigate the impact of iodinated contrast on the renal function and
hemodynamics in rats with chronic hyperglycemia and chronic kidney disease. A
total of 30 rats were divided into six groups; Sham: control of chronic renal
disease; Citrate: control of chronic hyperglycemia (CH); Nx5/6: rats with 5/6
nephrectomy; Chronic Hyperglycemia: rats receiving Streptozotocin 65?mg/kg; Nx5/6
+ IC: rats Nx5/6 received 6?mL/kg of IC; CH + IC: Chronic hyperglycemia rats
receiving 6?mL/kg of IC. Renal function (inulin clearance; urinary neutrophil
gelatinase-associated lipocalin, NGAL) and hemodynamics (arterial blood pressure;
renal blood flow; renal vascular resistance) were evaluated. Iodinated contrast
significantly increased urinary NGAL and reduced inulin clearance, while the
hemodynamics parameters showed changes in arterial blood pressure, renal blood
flow, and renal vascular resistance in both CKD and CH groups. The results
suggest that the iodinated contrast in risk factors models has important impact
on renal function and hemodynamics. NGAL was confirmed to play a role of
highlight in diagnosis of CI-AKI.
|Animals
[MESH]
|Contrast Media/*adverse effects/therapeutic use
[MESH]