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10.1016/j.yjmcc.2016.01.027 http://scihub22266oqcxt.onion/10.1016/j.yjmcc.2016.01.027 C4789097!4789097 !26829117     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26829117 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26829117 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Mol+Cell+Cardiol 2016 ; 92 (ä): 196-202 Nephropedia Template TP {{tp|p=26829117 |t=2016. "Canonical and non-canonical actions of GRK5 in the heart" |pdf=|usr=}}{{26829117 }} gab.com Text "Canonical and non-canonical actions of GRK5 in the heart" JO: J Mol Cell Cardiol http://www.kidney.de/pget.php?&tw=1&pmid=26829117 #FOAvip As the average world-wide lifespan continues to increase, heart failure (HF) has dramatically increased in incidence leading to the highest degree of mortality and morbidity of any disease presently studied. G protein-coupled receptors (GPCRs) play a prominent role in regulation of cardiovascular function. GPCRs are effectively "turned off" by GPCR kinases (GRKs) in a process known as "desensitization". GRKs 2 and 5 are highly expressed in the heart, and known to be upregulated in HF. Over the last 20years, the role of GRK2 in HF has been widely studied. However, until recently, the role of GRK5 in cardiac pathophysiology had yet to be elucidated. In the present review, we will focus on GRK5's role in the myocardium in normal physiology, and its apparent critical role in the progression of HF. Further, we will also present potential therapeutic strategies (i.e. small molecule inhibition, gene therapy) that may have potential in combating the deleterious effects of GRK5 in HF. Twit Text FOAVip "Canonical and non-canonical actions of GRK5 in the heart" ????J Mol Cell Cardiol http://www.kidney.de/pget.php?&tw=1&pmid=26829117 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26829117 #FOAvip English Wikipedia <ref>{{Cite pmid|26829117 }}</ref> "Canonical and non-canonical actions of GRK5 in the heart" #MMPMID26829117 Traynham CJ ; Hullmann J ; Koch WJ J Mol Cell Cardiol 2016[Mar]; 92 (ä): 196-202 PMID26829117 show ga As the average world-wide lifespan continues to increase, heart failure (HF) has dramatically increased in incidence leading to the highest degree of mortality and morbidity of any disease presently studied. G protein-coupled receptors (GPCRs) play a prominent role in regulation of cardiovascular function. GPCRs are effectively "turned off" by GPCR kinases (GRKs) in a process known as "desensitization". GRKs 2 and 5 are highly expressed in the heart, and known to be upregulated in HF. Over the last 20years, the role of GRK2 in HF has been widely studied. However, until recently, the role of GRK5 in cardiac pathophysiology had yet to be elucidated. In the present review, we will focus on GRK5's role in the myocardium in normal physiology, and its apparent critical role in the progression of HF. Further, we will also present potential therapeutic strategies (i.e. small molecule inhibition, gene therapy) that may have potential in combating the deleterious effects of GRK5 in HF. |G-Protein-Coupled Receptor Kinase 5/*genetics/metabolism [MESH] |Heart Failure/*genetics/metabolism/pathology [MESH] |Humans [MESH] |Molecular Targeted Therapy [MESH]"Canonical and non-canonical actions of GRK5 in the heart" (epmc).pdf DeepDyve Pubget Overpricing