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2016 ; 2016
(ä): 5768428
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Encephalitozoon cuniculi: Grading the Histological Lesions in Brain, Kidney, and
Liver during Primoinfection Outbreak in Rabbits
#MMPMID27022485
Rodríguez-Tovar LE
; Nevárez-Garza AM
; Trejo-Chávez A
; Hernández-Martínez CA
; Hernández-Vidal G
; Zarate-Ramos JJ
; Castillo-Velázquez U
J Pathog
2016[]; 2016
(ä): 5768428
PMID27022485
show ga
This is the first confirmed report of Encephalitozoon cuniculi (E. cuniculi) in
farm meat rabbits located in Northern Mexico. Eighty young rabbits exhibited
clinical signs of this zoonotic emerging disease, like torticollis, ataxia,
paresis, circling, and rolling. Samples of brain, kidney, and liver were examined
for histology lesions. For the first time the lesions caused by E. cuniculi were
graded according to their severity (I, II, and III) and the size of the
granulomas (Types A, B, and C). The main cerebral injuries were Grade III,
coinciding with the presence of Type C granulomas. The cerebral lesions were
located in the cortex, brain stem, and medulla. The renal lesions were also Grade
III distributed throughout cortex and renal medulla, with no granuloma formation.
The involvement of hypersensitivity Types III and IV is suggested. All of the
rabbits were seropositive to E. cuniculi by CIA testing, suggesting that this
zoonotic and emerging pathogen is widely distributed among animals intended for
human consumption. We believe this work could be used as a guide when examining
E. cuniculi and will provide direction to confirm the diagnosis of this pathogen.