Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27022209
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Mediators+Inflamm
2016 ; 2016
(ä): 5780903
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Angiopoietin-2 Is an Early Indicator of Acute Pancreatic-Renal Syndrome in
Patients with Acute Pancreatitis
#MMPMID27022209
Sporek M
; Dumnicka P
; Gala-Bladzinska A
; Ceranowicz P
; Warzecha Z
; Dembinski A
; Stepien E
; Walocha J
; Drozdz R
; Kuzniewski M
; Kusnierz-Cabala B
Mediators Inflamm
2016[]; 2016
(ä): 5780903
PMID27022209
show ga
Within the first week of the disease, acute kidney injury (AKI) is among the most
common causes of mortality in acute pancreatitis (AP). Recently, serum
angiopoietin-2 (Ang-2) has been associated with hyperdynamic state of the
systemic circulation. The aim of this study was to examine the associations
between Ang-2 and the clinical AP severity during the first 72 hours of the
disease, and organ disfunction, including AKI. Methods. Study included patients
admitted to the surgery ward, diagnosed with AP. AKI was diagnosed according to
KDIGO guidelines and renal failure according to modified Marshall scoring system.
Ang-2 was determined in serum with ELISA. Results. AP was classified as mild
(MAP) in 71% of patients, moderately severe (MSAP) in 22%, and severe (SAP) in
8%. During the first 72 hours of AP, 11 patients developed AKI and 6 developed
renal failure. Ang-2 at 24, 48, and 72 hours following the onset of AP symptoms
significantly predicted SAP and MSAP, as well as AKI and renal failure. Also,
Ang-2 significantly correlated with acute phase proteins as well as with the
indicators of renal disfunction. Conclusions. Serum Ang-2 may be a relevant
predictor of AP severity, in particular of the development of AP-renal syndrome.