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10.1186/s13104-016-1947-0 http://scihub22266oqcxt.onion/10.1186/s13104-016-1947-0 C4788823!4788823!26969411     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       BMC+Res+Notes 2016 ; 9 (ä): ä Nephropedia Template TP {{tp|p=26969411|t=2016. HiView: an integrative genome browser to leverage Hi-C results for the interpretation of GWAS variants |pdf=|usr=}}{{26969411}} gab.com Text HiView: an integrative genome browser to leverage Hi-C results for the interpretation of GWAS variants JO: BMC Res Notes http://www.kidney.de/pget.php?&tw=1&pmid=26969411 #FOAvip Background: Genome-wide association studies (GWAS) have identified thousands of genetic variants associated with complex traits and diseases. However, most of them are located in the non-protein coding regions, and therefore it is challenging to hypothesize the functions of these non-coding GWAS variants. Recent large efforts such as the ENCODE and Roadmap Epigenomics projects have predicted a large number of regulatory elements. However, the target genes of these regulatory elements remain largely unknown. Chromatin conformation capture based technologies such as Hi-C can directly measure the chromatin interactions and have generated an increasingly comprehensive catalog of the interactome between the distal regulatory elements and their potential target genes. Leveraging such information revealed by Hi-C holds the promise of elucidating the functions of genetic variants in human diseases. Results: In this work, we present HiView, the first integrative genome browser to leverage Hi-C results for the interpretation of GWAS variants. HiView is able to display Hi-C data and statistical evidence for chromatin interactions in genomic regions surrounding any given GWAS variant, enabling straightforward visualization and interpretation. Conclusions: We believe that as the first GWAS variants-centered Hi-C genome browser, HiView is a useful tool guiding post-GWAS functional genomics studies. HiView is freely accessible at: http://www.unc.edu/~yunmli/HiView. Electronic supplementary material: The online version of this article (doi:10.1186/s13104-016-1947-0) contains supplementary material, which is available to authorized users. Twit Text FOAVip HiView: an integrative genome browser to leverage Hi-C results for the interpretation of GWAS variants ????BMC Res Notes http://www.kidney.de/pget.php?&tw=1&pmid=26969411 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26969411 #FOAvip English Wikipedia <ref>{{Cite pmid|26969411}}</ref> HiView: an integrative genome browser to leverage Hi-C results for the interpretation of GWAS variants #MMPMID26969411 Xu Z; Zhang G; Duan Q; Chai S; Zhang B; Wu C; Jin F; Yue F; Li Y; Hu M BMC Res Notes 2016[]; 9 (ä): ä PMID26969411show ga Background: Genome-wide association studies (GWAS) have identified thousands of genetic variants associated with complex traits and diseases. However, most of them are located in the non-protein coding regions, and therefore it is challenging to hypothesize the functions of these non-coding GWAS variants. Recent large efforts such as the ENCODE and Roadmap Epigenomics projects have predicted a large number of regulatory elements. However, the target genes of these regulatory elements remain largely unknown. Chromatin conformation capture based technologies such as Hi-C can directly measure the chromatin interactions and have generated an increasingly comprehensive catalog of the interactome between the distal regulatory elements and their potential target genes. Leveraging such information revealed by Hi-C holds the promise of elucidating the functions of genetic variants in human diseases. Results: In this work, we present HiView, the first integrative genome browser to leverage Hi-C results for the interpretation of GWAS variants. HiView is able to display Hi-C data and statistical evidence for chromatin interactions in genomic regions surrounding any given GWAS variant, enabling straightforward visualization and interpretation. Conclusions: We believe that as the first GWAS variants-centered Hi-C genome browser, HiView is a useful tool guiding post-GWAS functional genomics studies. HiView is freely accessible at: http://www.unc.edu/~yunmli/HiView. Electronic supplementary material: The online version of this article (doi:10.1186/s13104-016-1947-0) contains supplementary material, which is available to authorized users. äHiView: an integrative genome browser to leverage Hi-C results for the(epmc).pdf DeepDyve Pubget Overpricing