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10.1016/j.cell.2016.02.007 http://scihub22266oqcxt.onion/10.1016/j.cell.2016.02.007 C4788811!4788811!26967279     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell 2016 ; 164 (6): 1110-21 Nephropedia Template TP {{tp|p=26967279|t=2016. The 3D genome as moderator of chromosomal communication |pdf=|usr=}}{{26967279}} gab.com Text The 3D genome as moderator of chromosomal communication JO: Cell http://www.kidney.de/pget.php?&tw=1&pmid=26967279 #FOAvip Proper expression of genes requires communication with their regulatory elements that can be located elsewhere along the chromosome. The physics of chromatin fibers imposes a range of constraints on such communication. The molecular and biophysical mechanisms by which chromosomal communication is established, or prevented, have become a topic of intense study, and important roles for the spatial organization of chromosomes are being discovered. Here we present a view of the interphase 3D genome characterized by extensive physical compartmentalization and insulation on the one hand and facilitated long-range interactions on the other. We propose the existence of topological machines dedicated to set up and to exploit a 3D genome organization to both promote and censor communication along and between chromosomes. Twit Text FOAVip The 3D genome as moderator of chromosomal communication ????Cell http://www.kidney.de/pget.php?&tw=1&pmid=26967279 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26967279 #FOAvip English Wikipedia <ref>{{Cite pmid|26967279}}</ref> The 3D genome as moderator of chromosomal communication #MMPMID26967279 Dekker J; Mirny L Cell 2016[Mar]; 164 (6): 1110-21 PMID26967279show ga Proper expression of genes requires communication with their regulatory elements that can be located elsewhere along the chromosome. The physics of chromatin fibers imposes a range of constraints on such communication. The molecular and biophysical mechanisms by which chromosomal communication is established, or prevented, have become a topic of intense study, and important roles for the spatial organization of chromosomes are being discovered. Here we present a view of the interphase 3D genome characterized by extensive physical compartmentalization and insulation on the one hand and facilitated long-range interactions on the other. We propose the existence of topological machines dedicated to set up and to exploit a 3D genome organization to both promote and censor communication along and between chromosomes. äThe 3D genome as moderator of chromosomal communication (epmc).pdf DeepDyve Pubget Overpricing