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10.1016/j.cell.2016.01.034

http://scihub22266oqcxt.onion/10.1016/j.cell.2016.01.034
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C4788809!4788809!26967283
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suck abstract from ncbi


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pmid26967283      Cell 2016 ; 164 (6): 1162-71
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  • The Nuclear Pore Complex as a Flexible and Dynamic Gate #MMPMID26967283
  • Knockenhauer KE; Schwartz TU
  • Cell 2016[Mar]; 164 (6): 1162-71 PMID26967283show ga
  • Nuclear pore complexes (NPCs) perforate the nuclear envelope and serve as the primary transport gates for molecular exchange between nucleus and cytoplasm. Stripping the megadalton complex down to its most essential organizational elements, one can divide the NPC into scaffold components, and the disordered elements attached to it that generate a selective barrier between compartments. These structural elements exhibit flexibility, which may hold a clue in understanding NPC assembly and function. Here we review the current status of NPC research with a focus on the functional implications of its structural and compositional heterogeneity.
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