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10.1016/j.stemcr.2016.01.004 http://scihub22266oqcxt.onion/10.1016/j.stemcr.2016.01.004 C4788761!4788761 !26876669     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26876669 &cmd=llinks): Failed to open stream: HTTP request failed! 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MicroRNAs for Fine-Tuning of Mouse Embryonic Stem Cell Fate Decision through Regulation of TGF-? Signaling |pdf=|usr=}}{{26876669 }} gab.com Text MicroRNAs for Fine-Tuning of Mouse Embryonic Stem Cell Fate Decision through Regulation of TGF- Signaling JO: Stem Cell Reports http://www.kidney.de/pget.php?&tw=1&pmid=26876669 #FOAvip Over the past years, microRNAs (miRNAs) have emerged as crucial factors that regulate self-renewal and differentiation of embryonic stem cells (ESCs). Although much is known about their role in maintaining ESC pluripotency, the mechanisms by which they affect cell fate decisions remain poorly understood. By performing deep sequencing to profile miRNA expression in mouse ESCs (mESCs) and differentiated embryoid bodies (EBs), we identified four differentially expressed miRNAs. Among them, miR-191 and miR-16-1 are highly expressed in ESCs and repress Smad2, the most essential mediator of Activin-Nodal signaling, resulting in the inhibition of mesendoderm formation. miR-23a, which is also down-regulated in the differentiated state, suppresses differentiation toward the endoderm and ectoderm lineages. We further identified miR-421 as a differentiation-associated regulator through the direct repression of the core pluripotency transcription factor Oct4 and the bone morphogenetic protein (BMP)-signaling components, Smad5 and Id2. Collectively, our findings uncover a regulatory network between the studied miRNAs and both branches of TGF-?/BMP-signaling pathways, revealing their importance for ESC lineage decisions. Twit Text FOAVip MicroRNAs for Fine-Tuning of Mouse Embryonic Stem Cell Fate Decision through Regulation of TGF- Signaling ????Stem Cell Reports http://www.kidney.de/pget.php?&tw=1&pmid=26876669 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26876669 #FOAvip English Wikipedia <ref>{{Cite pmid|26876669 }}</ref> MicroRNAs for Fine-Tuning of Mouse Embryonic Stem Cell Fate Decision through Regulation of TGF-? Signaling #MMPMID26876669 Hadjimichael C ; Nikolaou C ; Papamatheakis J ; Kretsovali A Stem Cell Reports 2016[Mar]; 6 (3 ): 292-301 PMID26876669 show ga Over the past years, microRNAs (miRNAs) have emerged as crucial factors that regulate self-renewal and differentiation of embryonic stem cells (ESCs). Although much is known about their role in maintaining ESC pluripotency, the mechanisms by which they affect cell fate decisions remain poorly understood. By performing deep sequencing to profile miRNA expression in mouse ESCs (mESCs) and differentiated embryoid bodies (EBs), we identified four differentially expressed miRNAs. Among them, miR-191 and miR-16-1 are highly expressed in ESCs and repress Smad2, the most essential mediator of Activin-Nodal signaling, resulting in the inhibition of mesendoderm formation. miR-23a, which is also down-regulated in the differentiated state, suppresses differentiation toward the endoderm and ectoderm lineages. We further identified miR-421 as a differentiation-associated regulator through the direct repression of the core pluripotency transcription factor Oct4 and the bone morphogenetic protein (BMP)-signaling components, Smad5 and Id2. Collectively, our findings uncover a regulatory network between the studied miRNAs and both branches of TGF-?/BMP-signaling pathways, revealing their importance for ESC lineage decisions. |*Cell Lineage [MESH] |*Signal Transduction [MESH] |Animals [MESH] |Bone Morphogenetic Proteins/metabolism [MESH] |Cell Differentiation [MESH] |Cell Line [MESH] |Embryonic Stem Cells/cytology/*metabolism [MESH] |Inhibitor of Differentiation Protein 2/metabolism [MESH] |Mice [MESH] |MicroRNAs/*genetics [MESH] |Octamer Transcription Factor-3/metabolism [MESH] |Smad2 Protein/metabolism [MESH] |Smad5 Protein/metabolism [MESH]MicroRNAs for Fine-Tuning of Mouse Embryonic Stem Cell Fate Decision t(epmc).pdf DeepDyve Pubget Overpricing