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10.1371/journal.ppat.1005490 http://scihub22266oqcxt.onion/10.1371/journal.ppat.1005490 C4788425!4788425!26967901     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26967901&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PLoS+Pathog 2016 ; 12 (3): ä Nephropedia Template TP {{tp|p=26967901|t=2016. TIM3 Mediates T Cell Exhaustion during Mycobacterium tuberculosis Infection |pdf=|usr=}}{{26967901}} gab.com Text TIM3 Mediates T Cell Exhaustion during Mycobacterium tuberculosis Infection JO: PLoS Pathog http://www.kidney.de/pget.php?&tw=1&pmid=26967901 #FOAvip While T cell immunity initially limits Mycobacterium tuberculosis infection, why T cell immunity fails to sterilize the infection and allows recrudescence is not clear. One hypothesis is that T cell exhaustion impairs immunity and is detrimental to the outcome of M. tuberculosis infection. Here we provide functional evidence for the development T cell exhaustion during chronic TB. Second, we evaluate the role of the inhibitory receptor T cell immunoglobulin and mucin domain?containing-3 (TIM3) during chronic M. tuberculosis infection. We find that TIM3 expressing T cells accumulate during chronic infection, co-express other inhibitory receptors including PD1, produce less IL-2 and TNF but more IL-10, and are functionally exhausted. Finally, we show that TIM3 blockade restores T cell function and improves bacterial control, particularly in chronically infected susceptible mice. These data show that T cell immunity is suboptimal during chronic M. tuberculosis infection due to T cell exhaustion. Moreover, in chronically infected mice, treatment with anti-TIM3 mAb is an effective therapeutic strategy against tuberculosis. Twit Text FOAVip TIM3 Mediates T Cell Exhaustion during Mycobacterium tuberculosis Infection ????PLoS Pathog http://www.kidney.de/pget.php?&tw=1&pmid=26967901 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26967901 #FOAvip English Wikipedia <ref>{{Cite pmid|26967901}}</ref> TIM3 Mediates T Cell Exhaustion during Mycobacterium tuberculosis Infection #MMPMID26967901 Jayaraman P; Jacques MK; Zhu C; Steblenko KM; Stowell BL; Madi A; Anderson AC; Kuchroo VK; Behar SM PLoS Pathog 2016[Mar]; 12 (3): ä PMID26967901show ga While T cell immunity initially limits Mycobacterium tuberculosis infection, why T cell immunity fails to sterilize the infection and allows recrudescence is not clear. One hypothesis is that T cell exhaustion impairs immunity and is detrimental to the outcome of M. tuberculosis infection. Here we provide functional evidence for the development T cell exhaustion during chronic TB. Second, we evaluate the role of the inhibitory receptor T cell immunoglobulin and mucin domain?containing-3 (TIM3) during chronic M. tuberculosis infection. We find that TIM3 expressing T cells accumulate during chronic infection, co-express other inhibitory receptors including PD1, produce less IL-2 and TNF but more IL-10, and are functionally exhausted. Finally, we show that TIM3 blockade restores T cell function and improves bacterial control, particularly in chronically infected susceptible mice. These data show that T cell immunity is suboptimal during chronic M. tuberculosis infection due to T cell exhaustion. Moreover, in chronically infected mice, treatment with anti-TIM3 mAb is an effective therapeutic strategy against tuberculosis. äTIM3 Mediates T Cell Exhaustion during Mycobacterium tuberculosis Infe(epmc).pdf DeepDyve Pubget Overpricing