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10.1093/nar/gkv853 http://scihub22266oqcxt.onion/10.1093/nar/gkv853 C4787795!4787795!26304537     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26304537&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nucleic+Acids+Res 2015 ; 43 (17): 8169-82 Nephropedia Template TP {{tp|p=26304537|t=2015. The mRNA related ceRNA?ceRNA landscape and significance across 20 major cancer types |pdf=|usr=}}{{26304537}} gab.com Text The mRNA related ceRNA ceRNA landscape and significance across 20 major cancer types JO: Nucleic Acids Res http://www.kidney.de/pget.php?&tw=1&pmid=26304537 #FOAvip Cross-talk between competitive endogenous RNAs (ceRNAs) through shared miRNAs represents a novel layer of gene regulation that plays important roles in the physiology and development of cancers. However, a global view of their system-level properties across various types of cancers is still unknown. Here, we constructed the mRNA related ceRNA?ceRNA interaction landscape across 20 cancer types by systematically analyzing molecular profiles of 5203 tumors and miRNA regulations. Our study highlights the conserved features shared by pan-cancer and higher similarity within similar origin cell type. Moreover, a core ceRNA network was identified. Function analysis identified a common theme of cancer hallmarks, however they exhibit phenotype-specific connectivity patterns. Besides, we found a marked rewiring in the ceRNA program between various cancers, and further revealed conserved and rewired network ceRNA hubs in each cancer, which were tensely competitive interactions to constitute conserved and cancer-specific modules. By providing mechanistic linkage between known cancer miRNAs, their mediated ceRNA?ceRNA interactions, and the associations with known cancer hallmarks, the inferred cancer ceRNA?ceRNA interaction landscape will serve as a powerful public resource for further biological discoveries of tumorigenesis. Twit Text FOAVip The mRNA related ceRNA ceRNA landscape and significance across 20 major cancer types ????Nucleic Acids Res http://www.kidney.de/pget.php?&tw=1&pmid=26304537 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26304537 #FOAvip English Wikipedia <ref>{{Cite pmid|26304537}}</ref> The mRNA related ceRNA?ceRNA landscape and significance across 20 major cancer types #MMPMID26304537 Xu J; Li Y; Lu J; Pan T; Ding N; Wang Z; Shao T; Zhang J; Wang L; Li X Nucleic Acids Res 2015[Sep]; 43 (17): 8169-82 PMID26304537show ga Cross-talk between competitive endogenous RNAs (ceRNAs) through shared miRNAs represents a novel layer of gene regulation that plays important roles in the physiology and development of cancers. However, a global view of their system-level properties across various types of cancers is still unknown. Here, we constructed the mRNA related ceRNA?ceRNA interaction landscape across 20 cancer types by systematically analyzing molecular profiles of 5203 tumors and miRNA regulations. Our study highlights the conserved features shared by pan-cancer and higher similarity within similar origin cell type. Moreover, a core ceRNA network was identified. Function analysis identified a common theme of cancer hallmarks, however they exhibit phenotype-specific connectivity patterns. Besides, we found a marked rewiring in the ceRNA program between various cancers, and further revealed conserved and rewired network ceRNA hubs in each cancer, which were tensely competitive interactions to constitute conserved and cancer-specific modules. By providing mechanistic linkage between known cancer miRNAs, their mediated ceRNA?ceRNA interactions, and the associations with known cancer hallmarks, the inferred cancer ceRNA?ceRNA interaction landscape will serve as a powerful public resource for further biological discoveries of tumorigenesis. äThe mRNA related ceRNA?ceRNA landscape and significance across 20 majo(epmc).pdf DeepDyve Pubget Overpricing