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10.1093/nar/gkv844 http://scihub22266oqcxt.onion/10.1093/nar/gkv844 C4787792!4787792 !26286192     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26286192 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nucleic+Acids+Res 2015 ; 43 (17 ): 8435-51 Nephropedia Template TP {{tp|p=26286192 |t=2015. Involvement of SRSF11 in cell cycle-specific recruitment of telomerase to telomeres at nuclear speckles |pdf=|usr=}}{{26286192 }} gab.com Text Involvement of SRSF11 in cell cycle-specific recruitment of telomerase to telomeres at nuclear speckles JO: Nucleic Acids Res http://www.kidney.de/pget.php?&tw=1&pmid=26286192 #FOAvip Telomerase, a unique ribonucleoprotein complex that contains the telomerase reverse transcriptase (TERT), the telomerase RNA component (TERC) and the TERC-binding protein dyskerin, is required for continued cell proliferation in stem cells and cancer cells. Here we identify SRSF11 as a novel TERC-binding protein that localizes to nuclear speckles, subnuclear structures that are enriched in pre-messenger RNA splicing factors. SRSF11 associates with active telomerase enzyme through an interaction with TERC and directs it to nuclear speckles specifically during S phase of the cell cycle. On the other hand, a subset of telomeres is shown to be constitutively present at nuclear speckles irrespective of cell cycle phase, suggesting that nuclear speckles could be the nuclear sites for telomerase recruitment to telomeres. SRSF11 also associates with telomeres through an interaction with TRF2, which facilitates translocation of telomerase to telomeres. Depletion of SRSF11 prevents telomerase from associating with nuclear speckles and disrupts telomerase recruitment to telomeres, thereby abrogating telomere elongation by telomerase. These findings suggest that SRSF11 acts as a nuclear speckle-targeting factor that is essential for telomerase association with telomeres through the interactions with TERC and TRF2, and provides a potential target for modulating telomerase activity in cancer. Twit Text FOAVip Involvement of SRSF11 in cell cycle-specific recruitment of telomerase to telomeres at nuclear speckles ????Nucleic Acids Res http://www.kidney.de/pget.php?&tw=1&pmid=26286192 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26286192 #FOAvip English Wikipedia <ref>{{Cite pmid|26286192 }}</ref> Involvement of SRSF11 in cell cycle-specific recruitment of telomerase to telomeres at nuclear speckles #MMPMID26286192 Lee JH ; Jeong SA ; Khadka P ; Hong J ; Chung IK Nucleic Acids Res 2015[Sep]; 43 (17 ): 8435-51 PMID26286192 show ga Telomerase, a unique ribonucleoprotein complex that contains the telomerase reverse transcriptase (TERT), the telomerase RNA component (TERC) and the TERC-binding protein dyskerin, is required for continued cell proliferation in stem cells and cancer cells. Here we identify SRSF11 as a novel TERC-binding protein that localizes to nuclear speckles, subnuclear structures that are enriched in pre-messenger RNA splicing factors. SRSF11 associates with active telomerase enzyme through an interaction with TERC and directs it to nuclear speckles specifically during S phase of the cell cycle. On the other hand, a subset of telomeres is shown to be constitutively present at nuclear speckles irrespective of cell cycle phase, suggesting that nuclear speckles could be the nuclear sites for telomerase recruitment to telomeres. SRSF11 also associates with telomeres through an interaction with TRF2, which facilitates translocation of telomerase to telomeres. Depletion of SRSF11 prevents telomerase from associating with nuclear speckles and disrupts telomerase recruitment to telomeres, thereby abrogating telomere elongation by telomerase. These findings suggest that SRSF11 acts as a nuclear speckle-targeting factor that is essential for telomerase association with telomeres through the interactions with TERC and TRF2, and provides a potential target for modulating telomerase activity in cancer. |*Cell Cycle/genetics [MESH] |Cell Line, Tumor [MESH] |Cell Nucleus Structures/*enzymology/genetics [MESH] |HeLa Cells [MESH] |Humans [MESH] |Protein Interaction Domains and Motifs [MESH] |RNA/metabolism [MESH] |Serine-Arginine Splicing Factors/chemistry/*metabolism [MESH] |Telomerase/chemistry/*metabolism [MESH] |Telomere Homeostasis [MESH] |Telomere/*enzymology [MESH]Involvement of SRSF11 in cell cycle-specific recruitment of telomerase(epmc).pdf DeepDyve Pubget Overpricing