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10.1093/nar/gkv1026 http://scihub22266oqcxt.onion/10.1093/nar/gkv1026 C4787778!4787778!26446993     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nucleic+Acids+Res 2015 ; 43 (20): 9856-73 Nephropedia Template TP {{tp|p=26446993|t=2015. Control of the localization and function of a miRNA silencing component TNRC6A by Argonaute protein |pdf=|usr=}}{{26446993}} gab.com Text Control of the localization and function of a miRNA silencing component TNRC6A by Argonaute protein JO: Nucleic Acids Res http://www.kidney.de/pget.php?&tw=1&pmid=26446993 #FOAvip GW182 family proteins play important roles in microRNA (miRNA)-mediated RNA silencing. They directly interact with Argonaute (Ago) proteins in processing bodies (P bodies), cytoplasmic foci involved in mRNA degradation and storage. Recently, we revealed that a human GW182 family protein, TNRC6A, is a nuclear-cytoplasmic shuttling protein, and its subcellular localization is regulated by its own nuclear localization signal and nuclear export signal. Regarding the further controlling mechanism of TNRC6A subcellular localization, we found that TNRC6A protein is tethered in P bodies by direct interaction with Ago2 under Ago2 overexpression condition in HeLa cells. Furthermore, it was revealed that such Ago proteins might be strongly tethered in the P bodies through Ago-bound small RNAs. Thus, our results indicate that TNRC6A subcellular localization is substantially controlled by the interaction with Ago proteins. Furthermore, it was also revealed that the TNRC6A subcellular localization affects the RNA silencing activity. Twit Text FOAVip Control of the localization and function of a miRNA silencing component TNRC6A by Argonaute protein ????Nucleic Acids Res http://www.kidney.de/pget.php?&tw=1&pmid=26446993 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26446993 #FOAvip English Wikipedia <ref>{{Cite pmid|26446993}}</ref> Control of the localization and function of a miRNA silencing component TNRC6A by Argonaute protein #MMPMID26446993 Nishi K; Takahashi T; Suzawa M; Miyakawa T; Nagasawa T; Ming Y; Tanokura M; Ui-Tei K Nucleic Acids Res 2015[Nov]; 43 (20): 9856-73 PMID26446993show ga GW182 family proteins play important roles in microRNA (miRNA)-mediated RNA silencing. They directly interact with Argonaute (Ago) proteins in processing bodies (P bodies), cytoplasmic foci involved in mRNA degradation and storage. Recently, we revealed that a human GW182 family protein, TNRC6A, is a nuclear-cytoplasmic shuttling protein, and its subcellular localization is regulated by its own nuclear localization signal and nuclear export signal. Regarding the further controlling mechanism of TNRC6A subcellular localization, we found that TNRC6A protein is tethered in P bodies by direct interaction with Ago2 under Ago2 overexpression condition in HeLa cells. Furthermore, it was revealed that such Ago proteins might be strongly tethered in the P bodies through Ago-bound small RNAs. Thus, our results indicate that TNRC6A subcellular localization is substantially controlled by the interaction with Ago proteins. Furthermore, it was also revealed that the TNRC6A subcellular localization affects the RNA silencing activity. äControl of the localization and function of a miRNA silencing componen(epmc).pdf DeepDyve Pubget Overpricing