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http://scihub22266oqcxt.onion/ C4787298!4787298!26973699     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Biol+(Beijing) 2015 ; 10 (6): 475-86 Nephropedia Template TP {{tp|p=26973699|t=2015. Smoothened regulation in response to Hedgehog stimulation |pdf=|usr=}}{{26973699}} gab.com Text Smoothened regulation in response to Hedgehog stimulation JO: Front Biol (Beijing) http://www.kidney.de/pget.php?&tw=1&pmid=26973699 #FOAvip The Hedgehog (Hh) signaling pathway play critical roles in embryonic development and adult tissue homeostasis. A critical step in Hh signal transduction is how Hh receptor Patched (Ptc) inhibits the atypical G protein-coupled receptor Smoothened (Smo) in the absence of Hh and how this inhibition is release by Hh stimulation. It is unlikely that Ptc inhibits Smo by direct interaction. Here we discuss how Hh regulates the phosphorylation and ubiquitination of Smo, leading to cell surface and ciliary accumulation of Smo in Drosophila and vertebrate cells, respectively. In addition, we discuss how PI(4)P phospholipid acts in between Ptc and Smo to regulate Smo phosphorylation and activation in response to Hh stimulation. Twit Text FOAVip Smoothened regulation in response to Hedgehog stimulation ????Front Biol (Beijing) http://www.kidney.de/pget.php?&tw=1&pmid=26973699 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26973699 #FOAvip English Wikipedia <ref>{{Cite pmid|26973699}}</ref> Smoothened regulation in response to Hedgehog stimulation #MMPMID26973699 Jiang K; Jia J Front Biol (Beijing) 2015[Dec]; 10 (6): 475-86 PMID26973699show ga The Hedgehog (Hh) signaling pathway play critical roles in embryonic development and adult tissue homeostasis. A critical step in Hh signal transduction is how Hh receptor Patched (Ptc) inhibits the atypical G protein-coupled receptor Smoothened (Smo) in the absence of Hh and how this inhibition is release by Hh stimulation. It is unlikely that Ptc inhibits Smo by direct interaction. Here we discuss how Hh regulates the phosphorylation and ubiquitination of Smo, leading to cell surface and ciliary accumulation of Smo in Drosophila and vertebrate cells, respectively. In addition, we discuss how PI(4)P phospholipid acts in between Ptc and Smo to regulate Smo phosphorylation and activation in response to Hh stimulation. äSmoothened regulation in response to Hedgehog stimulation (epmc).pdf DeepDyve Pubget Overpricing