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10.1038/mt.2016.5 http://scihub22266oqcxt.onion/10.1038/mt.2016.5 C4786935!4786935!26765770     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mol+Ther 2016 ; 24 (3): 465-74 Nephropedia Template TP {{tp|p=26765770|t=2016. Current Progress in Therapeutic Gene Editing for Monogenic Diseases |pdf=|usr=}}{{26765770}} gab.com Text Current Progress in Therapeutic Gene Editing for Monogenic Diseases JO: Mol Ther http://www.kidney.de/pget.php?&tw=1&pmid=26765770 #FOAvip Programmable nucleases allow defined alterations in the genome with ease-of-use, efficiency, and specificity. Their availability has led to accurate and widespread genome engineering, with multiple applications in basic research, biotechnology, and therapy. With regard to human gene therapy, nuclease-based gene editing has facilitated development of a broad range of therapeutic strategies based on both nonhomologous end joining and homology-dependent repair. This review discusses current progress in nuclease-based therapeutic applications for a subset of inherited monogenic diseases including cystic fibrosis, Duchenne muscular dystrophy, diseases of the bone marrow, and hemophilia and highlights associated challenges and future prospects. Twit Text FOAVip Current Progress in Therapeutic Gene Editing for Monogenic Diseases ????Mol Ther http://www.kidney.de/pget.php?&tw=1&pmid=26765770 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26765770 #FOAvip English Wikipedia <ref>{{Cite pmid|26765770}}</ref> Current Progress in Therapeutic Gene Editing for Monogenic Diseases #MMPMID26765770 Prakash V; Moore M; Yáņez-Muņoz RJ Mol Ther 2016[Mar]; 24 (3): 465-74 PMID26765770show ga Programmable nucleases allow defined alterations in the genome with ease-of-use, efficiency, and specificity. Their availability has led to accurate and widespread genome engineering, with multiple applications in basic research, biotechnology, and therapy. With regard to human gene therapy, nuclease-based gene editing has facilitated development of a broad range of therapeutic strategies based on both nonhomologous end joining and homology-dependent repair. This review discusses current progress in nuclease-based therapeutic applications for a subset of inherited monogenic diseases including cystic fibrosis, Duchenne muscular dystrophy, diseases of the bone marrow, and hemophilia and highlights associated challenges and future prospects. äCurrent Progress in Therapeutic Gene Editing for Monogenic Diseases (epmc).pdf DeepDyve Pubget Overpricing