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10.1038/mt.2016.10 http://scihub22266oqcxt.onion/10.1038/mt.2016.10 C4786923!4786923!26755333     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mol+Ther 2016 ; 24 (3): 430-46 Nephropedia Template TP {{tp|p=26755333|t=2016. Genome-editing Technologies for Gene and Cell Therapy |pdf=|usr=}}{{26755333}} gab.com Text Genome-editing Technologies for Gene and Cell Therapy JO: Mol Ther http://www.kidney.de/pget.php?&tw=1&pmid=26755333 #FOAvip Gene therapy has historically been defined as the addition of new genes to human cells. However, the recent advent of genome-editing technologies has enabled a new paradigm in which the sequence of the human genome can be precisely manipulated to achieve a therapeutic effect. This includes the correction of mutations that cause disease, the addition of therapeutic genes to specific sites in the genome, and the removal of deleterious genes or genome sequences. This review presents the mechanisms of different genome-editing strategies and describes each of the common nuclease-based platforms, including zinc finger nucleases, transcription activator-like effector nucleases (TALENs), meganucleases, and the CRISPR/Cas9 system. We then summarize the progress made in applying genome editing to various areas of gene and cell therapy, including antiviral strategies, immunotherapies, and the treatment of monogenic hereditary disorders. The current challenges and future prospects for genome editing as a transformative technology for gene and cell therapy are also discussed. Twit Text FOAVip Genome-editing Technologies for Gene and Cell Therapy ????Mol Ther http://www.kidney.de/pget.php?&tw=1&pmid=26755333 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26755333 #FOAvip English Wikipedia <ref>{{Cite pmid|26755333}}</ref> Genome-editing Technologies for Gene and Cell Therapy #MMPMID26755333 Maeder ML; Gersbach CA Mol Ther 2016[Mar]; 24 (3): 430-46 PMID26755333show ga Gene therapy has historically been defined as the addition of new genes to human cells. However, the recent advent of genome-editing technologies has enabled a new paradigm in which the sequence of the human genome can be precisely manipulated to achieve a therapeutic effect. This includes the correction of mutations that cause disease, the addition of therapeutic genes to specific sites in the genome, and the removal of deleterious genes or genome sequences. This review presents the mechanisms of different genome-editing strategies and describes each of the common nuclease-based platforms, including zinc finger nucleases, transcription activator-like effector nucleases (TALENs), meganucleases, and the CRISPR/Cas9 system. We then summarize the progress made in applying genome editing to various areas of gene and cell therapy, including antiviral strategies, immunotherapies, and the treatment of monogenic hereditary disorders. The current challenges and future prospects for genome editing as a transformative technology for gene and cell therapy are also discussed. äGenome-editing Technologies for Gene and Cell Therapy (epmc).pdf DeepDyve Pubget Overpricing