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10.1038/mt.2015.151 http://scihub22266oqcxt.onion/10.1038/mt.2015.151 C4786909!4786909!26373345     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mol+Ther 2016 ; 24 (3): 458-64 Nephropedia Template TP {{tp|p=26373345|t=2016. Genome Engineering Using Adeno-associated Virus: Basic and Clinical Research Applications |pdf=|usr=}}{{26373345}} gab.com Text Genome Engineering Using Adeno-associated Virus: Basic and Clinical Research Applications JO: Mol Ther http://www.kidney.de/pget.php?&tw=1&pmid=26373345 #FOAvip In addition to their broad potential for therapeutic gene delivery, adeno-associated virus (AAV) vectors possess the innate ability to stimulate homologous recombination in mammalian cells at high efficiencies. This process?referred to as AAV-mediated gene targeting?has enabled the introduction of a diverse array of genomic modifications both in vitro and in vivo. With the recent emergence of targeted nucleases, AAV-mediated genome engineering is poised for clinical translation. Here, we review key properties of AAV vectors that underscore its unique utility in genome editing. We highlight the broad range of genome engineering applications facilitated by this technology and discuss the strong potential for unifying AAV with targeted nucleases for next-generation gene therapy. Twit Text FOAVip Genome Engineering Using Adeno-associated Virus: Basic and Clinical Research Applications ????Mol Ther http://www.kidney.de/pget.php?&tw=1&pmid=26373345 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26373345 #FOAvip English Wikipedia <ref>{{Cite pmid|26373345}}</ref> Genome Engineering Using Adeno-associated Virus: Basic and Clinical Research Applications #MMPMID26373345 Gaj T; Epstein BE; Schaffer DV Mol Ther 2016[Mar]; 24 (3): 458-64 PMID26373345show ga In addition to their broad potential for therapeutic gene delivery, adeno-associated virus (AAV) vectors possess the innate ability to stimulate homologous recombination in mammalian cells at high efficiencies. This process?referred to as AAV-mediated gene targeting?has enabled the introduction of a diverse array of genomic modifications both in vitro and in vivo. With the recent emergence of targeted nucleases, AAV-mediated genome engineering is poised for clinical translation. Here, we review key properties of AAV vectors that underscore its unique utility in genome editing. We highlight the broad range of genome engineering applications facilitated by this technology and discuss the strong potential for unifying AAV with targeted nucleases for next-generation gene therapy. äGenome Engineering Using Adeno-associated Virus: Basic and Clinical Re(epmc).pdf DeepDyve Pubget Overpricing