Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26912567
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Clin+Microbiol+Rev
2016 ; 29
(2
): 239-90
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Methodological and Clinical Aspects of the Molecular Epidemiology of
Mycobacterium tuberculosis and Other Mycobacteria
#MMPMID26912567
Jagielski T
; Minias A
; van Ingen J
; Rastogi N
; Brzostek A
; ?aczek A
; Dziadek J
Clin Microbiol Rev
2016[Apr]; 29
(2
): 239-90
PMID26912567
show ga
Molecular typing has revolutionized epidemiological studies of infectious
diseases, including those of a mycobacterial etiology. With the advent of
fingerprinting techniques, many traditional concepts regarding transmission,
infectivity, or pathogenicity of mycobacterial bacilli have been revisited, and
their conventional interpretations have been challenged. Since the mid-1990s,
when the first typing methods were introduced, a plethora of other modalities
have been proposed. So-called molecular epidemiology has become an essential
subdiscipline of modern mycobacteriology. It serves as a resource for
understanding the key issues in the epidemiology of tuberculosis and other
mycobacterial diseases. Among these issues are disclosing sources of infection,
quantifying recent transmission, identifying transmission links, discerning
reinfection from relapse, tracking the geographic distribution and clonal
expansion of specific strains, and exploring the genetic mechanisms underlying
specific phenotypic traits, including virulence, organ tropism, transmissibility,
or drug resistance. Since genotyping continues to unravel the biology of
mycobacteria, it offers enormous promise in the fight against and prevention of
the diseases caused by these pathogens. In this review, molecular typing methods
for Mycobacterium tuberculosis and nontuberculous mycobacteria elaborated over
the last 2 decades are summarized. The relevance of these methods to the
epidemiological investigation, diagnosis, evolution, and control of mycobacterial
diseases is discussed.
free
free
free
