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10.1182/blood-2015-07-607903 http://scihub22266oqcxt.onion/10.1182/blood-2015-07-607903 C4786834!4786834!26787737     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Blood 2016 ; 127 (10): 1234-41 Nephropedia Template TP {{tp|p=26787737|t=2016. Linkage between the mechanisms of thrombocytopenia and thrombopoiesis |pdf=|usr=}}{{26787737}} gab.com Text Linkage between the mechanisms of thrombocytopenia and thrombopoiesis JO: Blood http://www.kidney.de/pget.php?&tw=1&pmid=26787737 #FOAvip Thrombocytopenia is defined as a status in which platelet numbers are reduced. Imbalance between the homeostatic regulation of platelet generation and destruction is 1 potential cause of thrombocytopenia. In adults, platelet generation is a 2-stage process entailing the differentiation of hematopoietic stem cells into mature megakaryocytes (MKs; known as megakaryopoiesis) and release of platelets from MKs (known as thrombopoiesis or platelet biogenesis). Until recently, information about the genetic defects responsible for congenital thrombocytopenia was only available for a few forms of the disease. However, investigations over the past 15 years have identified mutations in genes encoding >20 different proteins that are responsible for these disorders, which has advanced our understanding of megakaryopoiesis and thrombopoiesis. The underlying pathogenic mechanisms can be categorized as (1) defects in MK lineage commitment and differentiation, (2) defects in MK maturation, and (3) defect in platelet release. Using these developmental stage categories, we here update recently described mechanisms underlying megakaryopoiesis and thrombopoiesis and discuss the association between platelet generation systems and thrombocytopenia. Twit Text FOAVip Linkage between the mechanisms of thrombocytopenia and thrombopoiesis ????Blood http://www.kidney.de/pget.php?&tw=1&pmid=26787737 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26787737 #FOAvip English Wikipedia <ref>{{Cite pmid|26787737}}</ref> Linkage between the mechanisms of thrombocytopenia and thrombopoiesis #MMPMID26787737 Eto K; Kunishima S Blood 2016[Mar]; 127 (10): 1234-41 PMID26787737show ga Thrombocytopenia is defined as a status in which platelet numbers are reduced. Imbalance between the homeostatic regulation of platelet generation and destruction is 1 potential cause of thrombocytopenia. In adults, platelet generation is a 2-stage process entailing the differentiation of hematopoietic stem cells into mature megakaryocytes (MKs; known as megakaryopoiesis) and release of platelets from MKs (known as thrombopoiesis or platelet biogenesis). Until recently, information about the genetic defects responsible for congenital thrombocytopenia was only available for a few forms of the disease. However, investigations over the past 15 years have identified mutations in genes encoding >20 different proteins that are responsible for these disorders, which has advanced our understanding of megakaryopoiesis and thrombopoiesis. The underlying pathogenic mechanisms can be categorized as (1) defects in MK lineage commitment and differentiation, (2) defects in MK maturation, and (3) defect in platelet release. Using these developmental stage categories, we here update recently described mechanisms underlying megakaryopoiesis and thrombopoiesis and discuss the association between platelet generation systems and thrombocytopenia. äLinkage between the mechanisms of thrombocytopenia and thrombopoiesis (epmc).pdf DeepDyve Pubget Overpricing