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10.1038/srep22971 http://scihub22266oqcxt.onion/10.1038/srep22971 C4786799!4786799 !26965792     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26965792 &cmd=llinks): Failed to open stream: HTTP request failed! 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Vaginal Fibroblastic Cells from Women with Pelvic Organ Prolapse Produce Matrices with Increased Stiffness and Collagen Content |pdf=|usr=}}{{26965792 }} gab.com Text Vaginal Fibroblastic Cells from Women with Pelvic Organ Prolapse Produce Matrices with Increased Stiffness and Collagen Content JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26965792 #FOAvip Pelvic organ prolapse (POP) is characterised by the weakening of the pelvic floor support tissues, and often by subsequent prolapse of the bladder outside the body, i.e. cystocele. The bladder is kept in place by the anterior vaginal wall which consists of a dense extracellular matrix rich in collagen content that is maintained and remodelled by fibroblastic cells, i.e. fibroblasts and myofibroblasts. Since altered matrix production influences tissue quality, and myofibroblasts are involved in normal and pathological soft tissue repair processes, we evaluated matrix production of cells derived from pre- and post-menopausal POP and non-POP control anterior vaginal wall tissues. Results showed that cells from postmenopausal POP women deposited matrices with high percentage of collagen fibres with less anisotropic orientation and increased stiffness than those produced by controls. There was a transient increase in myofibroblastic phenotype that was lost after the peak of tissue remodelling. In conclusion, affected fibroblasts from postmenopausal prolapsed tissues produced altered matrices in vitro compared to controls. Such aberrant altered matrix production does not appear to be a consequence of abnormal phenotypical changes towards the myofibroblastic lineage. Twit Text FOAVip Vaginal Fibroblastic Cells from Women with Pelvic Organ Prolapse Produce Matrices with Increased Stiffness and Collagen Content ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26965792 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26965792 #FOAvip English Wikipedia <ref>{{Cite pmid|26965792 }}</ref> Vaginal Fibroblastic Cells from Women with Pelvic Organ Prolapse Produce Matrices with Increased Stiffness and Collagen Content #MMPMID26965792 Ruiz-Zapata AM ; Kerkhof MH ; Ghazanfari S ; Zandieh-Doulabi B ; Stoop R ; Smit TH ; Helder MN Sci Rep 2016[Mar]; 6 (ä): 22971 PMID26965792 show ga Pelvic organ prolapse (POP) is characterised by the weakening of the pelvic floor support tissues, and often by subsequent prolapse of the bladder outside the body, i.e. cystocele. The bladder is kept in place by the anterior vaginal wall which consists of a dense extracellular matrix rich in collagen content that is maintained and remodelled by fibroblastic cells, i.e. fibroblasts and myofibroblasts. Since altered matrix production influences tissue quality, and myofibroblasts are involved in normal and pathological soft tissue repair processes, we evaluated matrix production of cells derived from pre- and post-menopausal POP and non-POP control anterior vaginal wall tissues. Results showed that cells from postmenopausal POP women deposited matrices with high percentage of collagen fibres with less anisotropic orientation and increased stiffness than those produced by controls. There was a transient increase in myofibroblastic phenotype that was lost after the peak of tissue remodelling. In conclusion, affected fibroblasts from postmenopausal prolapsed tissues produced altered matrices in vitro compared to controls. Such aberrant altered matrix production does not appear to be a consequence of abnormal phenotypical changes towards the myofibroblastic lineage. |Collagen/*metabolism [MESH] |Extracellular Matrix/metabolism/pathology [MESH] |Female [MESH] |Fibroblasts/metabolism/pathology [MESH] |Humans [MESH] |Matrix Metalloproteinase 2/metabolism [MESH] |Matrix Metalloproteinase 9/metabolism [MESH] |Middle Aged [MESH] |Pelvic Floor/*pathology [MESH] |Pelvic Organ Prolapse/*pathology [MESH] |Postmenopause/metabolism/physiology [MESH]Vaginal Fibroblastic Cells from Women with Pelvic Organ Prolapse Produ(epmc).pdf DeepDyve Pubget Overpricing