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10.1074/jbc.M115.710582 http://scihub22266oqcxt.onion/10.1074/jbc.M115.710582 C4786731!4786731!26797127     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Biol+Chem 2016 ; 291 (11): 5986-96 Nephropedia Template TP {{tp|p=26797127|t=2016. Fibroblast Activation Protein Cleaves and Inactivates Fibroblast Growth Factor 21* |pdf=|usr=}}{{26797127}} gab.com Text Fibroblast Activation Protein Cleaves and Inactivates Fibroblast Growth Factor 21* JO: J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=26797127 #FOAvip FGF21 is a stress-induced hormone with potent anti-obesity, insulin-sensitizing, and hepatoprotective properties. Although proteolytic cleavage of recombinant human FGF21 in preclinical species has been observed previously, the regulation of endogenously produced FGF21 is not well understood. Here we identify fibroblast activation protein (FAP) as the enzyme that cleaves and inactivates human FGF21. A selective chemical inhibitor, immunodepletion, or genetic deletion of Fap stabilized recombinant human FGF21 in serum. In addition, administration of a selective FAP inhibitor acutely increased circulating intact FGF21 levels in cynomolgus monkeys. On the basis of our findings, we propose selective FAP inhibition as a potential therapeutic approach to increase endogenous FGF21 activity for the treatment of obesity, type 2 diabetes, non-alcoholic steatohepatitis, and related metabolic disorders. Twit Text FOAVip Fibroblast Activation Protein Cleaves and Inactivates Fibroblast Growth Factor 21* ????J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=26797127 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26797127 #FOAvip English Wikipedia <ref>{{Cite pmid|26797127}}</ref> Fibroblast Activation Protein Cleaves and Inactivates Fibroblast Growth Factor 21* #MMPMID26797127 Dunshee DR; Bainbridge TW; Kljavin NM; Zavala-Solorio J; Schroeder AC; Chan R; Corpuz R; Wong M; Zhou W; Deshmukh G; Ly J; Sutherlin DP; Ernst JA; Sonoda J J Biol Chem 2016[Mar]; 291 (11): 5986-96 PMID26797127show ga FGF21 is a stress-induced hormone with potent anti-obesity, insulin-sensitizing, and hepatoprotective properties. Although proteolytic cleavage of recombinant human FGF21 in preclinical species has been observed previously, the regulation of endogenously produced FGF21 is not well understood. Here we identify fibroblast activation protein (FAP) as the enzyme that cleaves and inactivates human FGF21. A selective chemical inhibitor, immunodepletion, or genetic deletion of Fap stabilized recombinant human FGF21 in serum. In addition, administration of a selective FAP inhibitor acutely increased circulating intact FGF21 levels in cynomolgus monkeys. On the basis of our findings, we propose selective FAP inhibition as a potential therapeutic approach to increase endogenous FGF21 activity for the treatment of obesity, type 2 diabetes, non-alcoholic steatohepatitis, and related metabolic disorders. äFibroblast Activation Protein Cleaves and Inactivates Fibroblast Growt(epmc).pdf DeepDyve Pubget Overpricing