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10.1074/jbc.M115.696849

http://scihub22266oqcxt.onion/10.1074/jbc.M115.696849
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C4786706!4786706!26797128
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suck abstract from ncbi


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pmid26797128      J+Biol+Chem 2016 ; 291 (11): 5664-75
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  • PKD1 Inhibits AMPK?2 through Phosphorylation of Serine 491 and Impairs Insulin Signaling in Skeletal Muscle Cells* #MMPMID26797128
  • Coughlan KA; Valentine RJ; Sudit BS; Allen K; Dagon Y; Kahn BB; Ruderman NB; Saha AK
  • J Biol Chem 2016[Mar]; 291 (11): 5664-75 PMID26797128show ga
  • Background: Diminished activity of the enzyme AMP-activated protein kinase (AMPK) is associated with impaired insulin signaling.Results: Protein Kinase (PK)C/D1 activation inhibits AMPK?2 via Ser491 phosphorylation; PKD1 inhibition prevents this in skeletal muscle cells.Conclusion: PKD1 is a novel upstream AMPK-kinase that phosphorylates AMPK on Ser491 and regulates insulin signaling.Significance: PKD1 inhibition may be a novel strategy for improving insulin sensitivity.
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