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10.1038/nrgastro.2015.111 http://scihub22266oqcxt.onion/10.1038/nrgastro.2015.111 C4786374!4786374!26122478     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Rev+Gastroenterol+Hepatol 2015 ; 12 (8): 446-57 Nephropedia Template TP {{tp|p=26122478|t=2015. Secretory diarrhoea: mechanisms and emerging therapies |pdf=|usr=}}{{26122478}} gab.com Text Secretory diarrhoea: mechanisms and emerging therapies JO: Nat Rev Gastroenterol Hepatol http://www.kidney.de/pget.php?&tw=1&pmid=26122478 #FOAvip Diarrhoeal disease remains a major health burden worldwide. Secretory diarrhoeas are caused by certain bacterial and viral infections, inflammatory processes, drugs and genetic disorders. Fluid secretion across the intestinal epithelium in secretory diarrhoeas involves multiple ion and solute transporters, as well as activation of cyclic nucleotide and Ca2+ signalling pathways. In many secretory diarrhoeas, activation of Cl? channels in the apical membrane of enterocytes, including the cystic fibrosis transmembrane conductance regulator and Ca2+-activated Cl? channels, increases fluid secretion, while inhibition of Na+ transport reduces fluid absorption. Current treatment of diarrhoea includes replacement of fluid and electrolyte losses using oral rehydration solutions, and drugs targeting intestinal motility or fluid secretion. Therapeutics in the development pipeline target intestinal ion channels and transporters, regulatory proteins and cell surface receptors. This Review describes pathogenic mechanisms of secretory diarrhoea, current and emerging therapeutics, and the challenges in developing antidiarrhoeal therapeutics. Twit Text FOAVip Secretory diarrhoea: mechanisms and emerging therapies ????Nat Rev Gastroenterol Hepatol http://www.kidney.de/pget.php?&tw=1&pmid=26122478 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26122478 #FOAvip English Wikipedia <ref>{{Cite pmid|26122478}}</ref> Secretory diarrhoea: mechanisms and emerging therapies #MMPMID26122478 Thiagarajah JR; Donowitz M; Verkman AS Nat Rev Gastroenterol Hepatol 2015[Aug]; 12 (8): 446-57 PMID26122478show ga Diarrhoeal disease remains a major health burden worldwide. Secretory diarrhoeas are caused by certain bacterial and viral infections, inflammatory processes, drugs and genetic disorders. Fluid secretion across the intestinal epithelium in secretory diarrhoeas involves multiple ion and solute transporters, as well as activation of cyclic nucleotide and Ca2+ signalling pathways. In many secretory diarrhoeas, activation of Cl? channels in the apical membrane of enterocytes, including the cystic fibrosis transmembrane conductance regulator and Ca2+-activated Cl? channels, increases fluid secretion, while inhibition of Na+ transport reduces fluid absorption. Current treatment of diarrhoea includes replacement of fluid and electrolyte losses using oral rehydration solutions, and drugs targeting intestinal motility or fluid secretion. Therapeutics in the development pipeline target intestinal ion channels and transporters, regulatory proteins and cell surface receptors. This Review describes pathogenic mechanisms of secretory diarrhoea, current and emerging therapeutics, and the challenges in developing antidiarrhoeal therapeutics. äSecretory diarrhoea: mechanisms and emerging therapies (epmc).pdf DeepDyve Pubget Overpricing