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10.1038/nri3843 http://scihub22266oqcxt.onion/10.1038/nri3843 C4786079!4786079!25976513     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Rev+Immunol 2015 ; 15 (6): 335-49 Nephropedia Template TP {{tp|p=25976513|t=2015. Fever and the thermal regulation of immunity: the immune system feels the heat |pdf=|usr=}}{{25976513}} gab.com Text Fever and the thermal regulation of immunity: the immune system feels the heat JO: Nat Rev Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25976513 #FOAvip Fever is a cardinal response to infection that has been conserved in warm and cold-blooded vertebrates for over 600 million years of evolution. The fever response is executed by integrated physiological and neuronal circuitry and confers a survival benefit during infection. Here, we review our current understanding of how the inflammatory cues delivered by the thermal element of fever stimulate innate and adaptive immune responses. We further highlight the unexpected multiplicity of roles of the pyrogenic cytokine interleukin-6 (IL-6), both during fever induction as well as during the mobilization of lymphocytes to the lymphoid organs that are the staging ground for immune defence. Finally, we discuss the emerging evidence that suggests the adrenergic signalling pathways associated with thermogenesis shape immune cell function. Twit Text FOAVip Fever and the thermal regulation of immunity: the immune system feels the heat ????Nat Rev Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25976513 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25976513 #FOAvip English Wikipedia <ref>{{Cite pmid|25976513}}</ref> Fever and the thermal regulation of immunity: the immune system feels the heat #MMPMID25976513 Evans SS; Repasky EA; Fisher DT Nat Rev Immunol 2015[Jun]; 15 (6): 335-49 PMID25976513show ga Fever is a cardinal response to infection that has been conserved in warm and cold-blooded vertebrates for over 600 million years of evolution. The fever response is executed by integrated physiological and neuronal circuitry and confers a survival benefit during infection. Here, we review our current understanding of how the inflammatory cues delivered by the thermal element of fever stimulate innate and adaptive immune responses. We further highlight the unexpected multiplicity of roles of the pyrogenic cytokine interleukin-6 (IL-6), both during fever induction as well as during the mobilization of lymphocytes to the lymphoid organs that are the staging ground for immune defence. Finally, we discuss the emerging evidence that suggests the adrenergic signalling pathways associated with thermogenesis shape immune cell function. äFever and the thermal regulation of immunity: the immune system feels (epmc).pdf DeepDyve Pubget Overpricing