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Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Biosens+Bioelectron 2016 ; 80 (ä): 273-87 Nephropedia Template TP
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Nano-biosensors to detect beta-amyloid for Alzheimer?s disease management #MMPMID26851586
Kaushik A; Jayant RD; Tiwari S; Vashist A; Nair M
Biosens Bioelectron 2016[Jun]; 80 (ä): 273-87 PMID26851586show ga
Beta-amyloid (?-A) peptides are potential biomarkers to monitor Alzheimer?s diseases (AD) for diagnostic purposes. Increased ?-A level is neurotoxic and induces oxidative stress in brain resulting in neurodegeneration and causes dementia. As of now, no sensitive and inexpensive method is available for ?-A detection under physiological and pathological conditions. Although, available methods such as neuroimaging, enzyme-linked immunosorbent assay (ELISA), and polymerase chain reaction (PCR) detect ?-A, but they are not yet extended at point-of-care (POC) due to sophisticated equipments, need of high expertise, complicated operations, and challenge of low detection limit. Recently, ?-A antibody based electrochemical immuno-sensing approach has been explored to detect ?-A at pM levels within 30?40 minutes compared to 6?8 hours of ELISA test. The introduction of nano-enabling electrochemical sensing technology could enable rapid detection of ?-A at POC and may facilitate fast personalized health care delivery. This review explores recent advancements in nano-enabling electrochemical ?-A sensing technologies towards POC application to AD management. These analytical tools can serve as an analytical tool for AD management program to obtain bio-informatics needed to optimize therapeutics for neurodegenerative diseases diagnosis management