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10.1016/j.bios.2016.01.065

http://scihub22266oqcxt.onion/10.1016/j.bios.2016.01.065
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C4786026!4786026!26851586
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suck abstract from ncbi


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pmid26851586      Biosens+Bioelectron 2016 ; 80 (ä): 273-87
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  • Nano-biosensors to detect beta-amyloid for Alzheimer?s disease management #MMPMID26851586
  • Kaushik A; Jayant RD; Tiwari S; Vashist A; Nair M
  • Biosens Bioelectron 2016[Jun]; 80 (ä): 273-87 PMID26851586show ga
  • Beta-amyloid (?-A) peptides are potential biomarkers to monitor Alzheimer?s diseases (AD) for diagnostic purposes. Increased ?-A level is neurotoxic and induces oxidative stress in brain resulting in neurodegeneration and causes dementia. As of now, no sensitive and inexpensive method is available for ?-A detection under physiological and pathological conditions. Although, available methods such as neuroimaging, enzyme-linked immunosorbent assay (ELISA), and polymerase chain reaction (PCR) detect ?-A, but they are not yet extended at point-of-care (POC) due to sophisticated equipments, need of high expertise, complicated operations, and challenge of low detection limit. Recently, ?-A antibody based electrochemical immuno-sensing approach has been explored to detect ?-A at pM levels within 30?40 minutes compared to 6?8 hours of ELISA test. The introduction of nano-enabling electrochemical sensing technology could enable rapid detection of ?-A at POC and may facilitate fast personalized health care delivery. This review explores recent advancements in nano-enabling electrochemical ?-A sensing technologies towards POC application to AD management. These analytical tools can serve as an analytical tool for AD management program to obtain bio-informatics needed to optimize therapeutics for neurodegenerative diseases diagnosis management
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